Overview

This unique book provides a concise account, written by world authorities in their fields, of how the mammalian lung grows and matures before birth and how the lungs, and their ability to function well, can be affected by the environment and by genetic factors, both before and after birth. It provides an understanding of the basis of some major lung diseases affecting infants and children. The book also deals with how the lung changes with age, and how the process of lung aging can be affected by the environment.

Full Product Details

Author:   Kent Pinkerton (Professor of Pediatrics, School of Medicine, University of California, Davis, USA) ,  Richard Harding (Emeritus Professor, Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia) ,  Charles Plopper (University of California, Davis, USA) ,  Richard Harding (Monash University, Clayton, Australia)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.00cm , Height: 2.50cm , Length: 27.90cm
Weight:   1.490kg
ISBN:  

9780123247513

ISBN 10:   0123247519
Pages:   424
Publication Date:   21 November 2003
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780127999418
Format:   Paperback
Publisher's Status:   Unknown
Availability:   Out of stock  

Table of Contents

Preface Introduction CRITICAL EVENTS IN NORMAL DEVELOPMENT AND AGING Lung Morphogenesis, role of growth factors and transcription factors Development of Airway Epithelium Development of the Airway Innervation Development of Alveoli Development of the Pulmonary Basement Membrane Development of the Pulmonary Vascular Developmental Physiology of the Pulmonary Circulation Development of Fluid Transport Across Pulmonary Epithelia Physical, Endocrine and Growth Factors in Lung Development Development of the Pulmonary Surfactant System Development of the Pulmonary Immune System Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems Compensatory Lung Growth Pulmonary Transition at Birth Normal Aging of the Lung ENVIRONMENTAL INFLUENCES ON LUNG DEVELOPMENT AND AGING Pulmonary Consequences of Premature Birth Role of Nutrition in Lung Development Before and After Birth Influence of High Altitude on Lung Development and Function Genetic Factors Involved in Susceptibility to Lung Disease Effects of Environmental Tobacco Smoke on Lung Development Nicotine Exposure During Early Development- effects on the lung Exposure to Allergens During Development Development of Atopy in Children Effects of Air Pollution on Lung Function Development and Asthma Occurence Environmental Toxicants and Lung Development in Experimental Models Repair of Environmental Lung Injury During Development Effects of Aging, Disease and the Environment on the Pulmonary Surfactant System Environmental Determinants of Lung Aging

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Author Information

Kent Pinkerton, MD, is professor of pediatrics, School of Medicine, and director of the Center for Health and the Environment at the University of California, Davis. His research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular, and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development. He is associate director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. He is also the associate director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting. Richard Harding is a NHMRC Senior Principal Research Fellow and an Emeritus Professor with the Department of Anatomy and Developmental Biology at Monash University, Australia. His research focuses on Respiratory Development and Programming. He is now semi-retired.

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