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OverviewFull Product DetailsAuthor: Md. Shahidul IslamPublisher: Springer Imprint: Springer Edition: 2010 ed. Volume: 654 Dimensions: Width: 15.50cm , Height: 4.30cm , Length: 23.50cm Weight: 1.235kg ISBN: 9789400731943ISBN 10: 9400731949 Pages: 798 Publication Date: 28 May 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsMicroscopic Anatomy of the Human Islet of Langerhans.- The Comparative Anatomy of Islets.- Approaches for Imaging Islets: Recent Advances and Future Prospects.- Islet Cell Development.- High Fat Programming of ?-Cell Failure.- Nutrient Regulation of Insulin Secretion and ?-Cell Functional Integrity.- Electrophysiology of Islet Cells.- ATP-Sensitive Potassium Channels in Health and Disease.- Role of Mitochondria in ?-cell Function and Dysfunction.- Basement Membrane in Pancreatic Islet Function.- Calcium Signaling in the Islets.- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets.- Cyclic AMP Signaling in Pancreatic Islets.- Exocytosis in Islet ?-Cells.- The Novel Roles of Glucagon-Like Peptide-1, Angiotensin II, and Vitamin D in Islet Function.- Proteomics and Islet Research.- Wnt Signaling in Pancreatic Islets.- Molecular Pathways Underlying the Pathogenesis of Pancreatic ?-Cell Dysfunction.- Mechanisms of Pancreatic ?-Cell Apoptosis in Diabetes and Its Therapies.- ?-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice].- Islet Structure and Function in the GK Rat.- The ?-Cell in Human Type 2 Diabetes.- Clinical Approaches to Preserve ?-Cell Function in Diabetes.- Immunology of ?-Cell Destruction.- Toll-Like Receptors and Type 1 Diabetes.- Prevention of ?-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects.- In Vivo Regeneration of Insulin-Producing ?-Cells.- Customized Cell-Based Treatment Options to Combat Autoimmunity and Restore ?-Cell Function in Type 1 Diabetes Mellitus: Current Protocols and Future Perspectives.- The Programmable Cell of Monocytic Origin (PCMO): A Potential Adult Stem/Progenitor Cell Source for the Generation of Islet Cells.- Islet Isolation for ClinicalTransplantation.- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead.- Modulation of Early Inflammatory Reactions to Promote Engraftment and Function of Transplanted Pancreatic Islets in Autoimmune Diabetes.- Successes and Disappointments with Clinical Islet Transplantation.- Islet Cell Tumours.Reviews""It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!"" Matthias von Herrath, MD Professor and Director, Center for Type 1 Diabetes Research La Jolla Institute for Allergy and Immunology, La Jolla CA, USA ""This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge"". Martha Pavlakis, MD Associate Professor of Medicine, Harvard Medical School Medical Director, Kidney and Pancreas Transplantation Beth Israel Deaconess Medical Center Boston, MA, USA ""The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely"". Fred Levine, M.D., Ph.D. Professor, Burnham Institute for Medical Research Director, Sanford Children's Health Research Center La Jolla, CA, USA ""The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource"". Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical School Minneapolis, MN, USA ""This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, butalso provide him with clues and keys for future exploration of still hidden sites"". Prof. Pellegrino Masiello Dept. of Experimental Pathology, University of Pisa, Pisa, Italy ""The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes"". Alvin C. Powers, M.D. Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and Biophysics Director, Vanderbilt Diabetes Center Vanderbilt University Nashville, TN USA ""A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research"" Marc Prentki, PhD Professor of Nutrition and Biochemistry Canada Research Chair in Diabetes and Metabolism MDRC Director Montreal, QC Canada It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice! Matthias von Herrath, MD Professor and Director, Center for Type 1 Diabetes Research La Jolla Institute for Allergy and Immunology, La Jolla CA, USA This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge . Martha Pavlakis, MD Associate Professor of Medicine, Harvard Medical School Medical Director, Kidney and Pancreas Transplantation Beth Israel Deaconess Medical Center Boston, MA, USA The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely . Fred Levine, M.D., Ph.D. Professor, Burnham Institute for Medical Research Director, Sanford Children's Health Research Center La Jolla, CA, USA The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource . Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical School Minneapolis, MN, USA This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites . Prof. Pellegrino Masiello Dept. of Experimental Pathology, University of Pisa, Pisa, Italy The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes . Alvin C. Powers, M.D. Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and Biophysics Director, Vanderbilt Diabetes Center Vanderbilt University Nashville, TN USA A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ss-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research Marc Prentki, PhD Professor of Nutrition and Biochemistry Canada Research Chair in Diabetes and Metabolism MDRC Director Montreal, QC Canada It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice! Matthias von Herrath, MD Professor and Director, Center for Type 1 Diabetes Research La Jolla Institute for Allergy and Immunology, La Jolla CA, USA This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge . Martha Pavlakis, MD Associate Professor of Medicine, Harvard Medical School Medical Director, Kidney and Pancreas Transplantation Beth Israel Deaconess Medical Center Boston, MA, USA The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely . Fred Levine, M.D., Ph.D. Professor, Burnham Institute for Medical Research Director, Sanford Children's Health Research Center La Jolla, CA, USA The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource . Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical School Minneapolis, MN, USA This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites . Prof. Pellegrino Masiello Dept. of Experimental Pathology, University of Pisa, Pisa, Italy The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes . Alvin C. Powers, M.D. Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and Biophysics Director, Vanderbilt Diabetes Center Vanderbilt University Nashville, TN USA A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ss-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research Marc Prentki, PhD Professor of Nutrition and Biochemistry Canada Research Chair in Diabetes and Metabolism MDRC Director Montreal, QC Canada Author InformationTab Content 6Author Website:Countries AvailableAll regions |