Overview

The nature of rapid (nongenomic) steroid signaling has been re-probed with experimental tools. Cellular responses to steroids start with membrane-initiated signals, eventually culminating in major transcriptional commitment and overhaul of cellular components. While much is known about the execution of the ultimate decision, little is known about how reception and processing of the first steroid signal notifies the cell of impending change. Therefore, it is very important to establish the identity of the proteins initiating these cellular responses. This text juxtaposes identifications from different laboratories and presents several possibilities: nuclear steroid receptor-like forms in non-nuclear locations, other known membrane receptors or channels with additional steroid binding sites, enzymes, transporters, receptors for serum steroid-binding proteins, and unique, previously undescribed proteins.

Full Product Details

Author:   Cheryl S. Watson
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2003 ed.
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   1.090kg
ISBN:  

9781402073441

ISBN 10:   1402073445
Pages:   208
Publication Date:   28 February 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Nuclear receptors in the Membrane. 1. Membrane-associated estrogen receptors and breast cancer; D.C. Márquez, R.J. Pietras. 2. A membrane form of estrogen receptor-alpha mediates estrogenic, nongenomic effects; C.S. Watso, et al. 3. An expanded view of estrogen receptor localization in neurons; T.A. Milner, et al. 4. Regulation of endothelial no synthase activity by estrogen receptors in a steroid receptor fast-action complex (SRFC); P.W. Shaul. 5. Estrogen-stimulated, membrane-initiated receptor-ligand interactions in vascular cells; Lei Li, et al. 6. Membrane glucocorticoid receptors and glucocorticoid signal transduction; B. Gametchu, C.S. Watson. 7. Nuclear vitamin D (VDR) and estrogen (ER) receptors in the membrane of muscle and breast cancer cells; D. Capiati, et al. Nuclear Receptors Physically Interact with Signal Cascade Molecules. 8. The role of adapter proteins in ERalpha membrane association and function; R. X.-D. Song, R. Kumar. 9. Interactions of estrogen receptors with signal cascade molecules; F. Auricchio, et al. 10. Human progesterone receptor cross-talk with cytoplasmic signaling molecules through direct SH3 domain interaction; V. Boonyaratanakornkit, D.P. Edwards. 11. The classical progesterone receptor mediates Xenopus oocyte maturation through a non-genomic mechanism; X.J. Liu, J.V. Ruderman. 12. Steroid hormone receptor interactions with PAK6. a member of the P21 activated kinase family; S.P. Balk, S.R. Lee. 13. Membrane localization and rapid non-transcriptional action of the androgen receptor; S. Mink, et al. 14. The discovery ofand function of MTA1s in ER&agr; cytoplasmic sequestration; Rui-An-Wang, R. Kumar. Unique, Previously Undescribed Receptors. 15. Novel, membrane-intrinsic receptors for progesterone and aldosterone; R. Lösel, et al. 16. Current knowledge of the nature and identity of progestin and estrogen membrane receptors in fish gonads; P. Thomas, et al. 17. Evidence supporting a role for GPR30, an orphan member of the G-protein coupled receptor superfamily, in rapid estrogen signaling; E.J. Filardo, et al. 18. A novel non-genomic action of estradiol (E) and testosterone (T): Regulators of microtubule polymerization; V.D. Ramirez, Jingjing Liu Kipp. 19. Evidence that a membrane corticosteroid receptor is an opioid-like receptor; F.L. Moore. 20. Progestins have actions through GABAA receptors; C.A. Frye, S.M. Petralia. 21. Characteristics of a nonclassical membrane estrogen receptor in the endocrine pancreas; A.B. Ropero, A. Nadal. Proteins with Identities or Similarities to Other Non-Receptor Proteins. 22. Protein kinase C isoforms as non-genomic receptors; B.J. Harvey, C.M. Doolan. Chimeras. 23. Membrane estrogen receptors in human spermatozoa: an example of a non-classic steroid receptor located in the membrane; S.M. Kahn, et al. Index.

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