Overview

This book provides a comprehensive survey of the structure and fibre connections of the human midbrain, specifically of the substantia nigra and ventral tegmental area. The cellular and chemical architecture of these structures are analyzed and their fibre connections are discussed. The role that they play in degenerative diseases of the nervous system, such as Alzheimer's and Parkinson's diseases, is evaluated. Some functional and pathophysiological considerations are included.

Full Product Details

Author:   Peter H.M.F. van Domburg ,  Hendrik J. ten Donkelaar
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   121
Dimensions:   Width: 17.00cm , Height: 0.80cm , Length: 24.20cm
Weight:   0.325kg
ISBN:  

9783540528234

ISBN 10:   3540528237
Pages:   132
Publication Date:   14 January 1991
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1 Introduction.- 2 Materials and Techniques.- 2.1 Cytoarchitectonic Analysis.- 2.2 Quantitative Analysis.- 2.3 Immunohistochemical Procedures.- 2.4 Neuropathological Procedures.- 3 Comparative and Developmental Notes.- 3.1 The SN and VTA in Lower Tetrapods.- 3.2 The Mammalian SN and VTA.- 3.3 Development of the SN and VTA.- 4 The Human Substantia Nigra and Ventral Tegmental Area.- 4.1 Introduction.- 4.2 Cytological Features.- 4.3 Cytoarchitectonic Subdivision.- 4.4 Chemoarchitecture.- 4.5 Fiber Connections of the Primate SN Complex.- 4.6 A Model of Human Nigral Organization.- 5 Neuropathological Aspects.- 5.1 Introduction.- 5.2 Involvement of the SN and VTA in Basal Ganglia Diseases.- 5.3 Involvement of the SN and VTA in AD.- 6 Quantitative Aspects.- 6.1 Introduction.- 6.2 Age-Related Neuronal Loss.- 6.3 Neuronal Loss in the SN and VTA in AD and PD.- 7 Functional and Pathophysiological Considerations.- 7.1 Lesion Studies on the SN.- 7.2 Some Functional and Pathophysiological Aspects of Mesencephalic DAergic Projections.- 7.3 The Involvement of the SN and VTA in AD and PD.- 8 Summary.- Acknowledgements.- References.

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