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The Hidden World of Protein Aggregation

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Author:   David B. Teplow (Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA) ,  Bahareh Dabirmanesh (Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran-Iran) ,  Vladimir N. Uversky (PhD, DSc, FRSB, FRSC, FAIMBE, Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.950kg
ISBN:  

9780443293405

ISBN 10:   0443293406
Pages:   528
Publication Date:   06 June 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Preface Bahareh Dabirmanesh and Vladimir N. Uversky 1. Protein Aggregation: An Overview Vladimir N. Uversky 2. Pathways of Amyloid Fibril Formation and Aggregation Bahareh Dabirmanesh and Fatemeh Aziziyan 3. Factors Influencing Amyloid Fibril Formation Khosro Khajeh and Fatemeh Aziziyan 4. Morphological Features and Types of Aggregated Structures Vladimir N. Uversky 5. Each big journey starts with a first step: Importance of Oligomerization Vladimir N. Uversky 6. Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation Vladimir N. Uversky 7. Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils Bahareh Dabirmanesh and Farnoosh Farzam 8. Prediction of Protein Aggregation Khosro Khajeh 9. Amyloid Fibril Cytotoxicity and Associated Disorders Khosro Khajeh 10. Inhibitors of Amyloid Fibril Formation Khosro Khajeh and Fatemeh Aziziyan 11. Therapeutic Approaches in Proteinopathies Vladimir N. Uversky 12. Functional Amyloids Bahareh Dabirmanesh 13. Biotechnological Applications of Amyloid Fibrils Bahareh Dabirmanesh 14. The Hidden World of Protein Aggregation Bahareh Dabirmanesh and Vladimir N. Uversky

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Author Information

David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid β-protein (Alzheimer's disease) and α-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease. Bahareh Dabirmanesh received her Ph.D. in Biochemistry from Tarbiat Modares University (Tehran-Iran) in 2013. Following the completion of her doctoral studies, she joined the University as an academic member pursuing both academic and research activities within the Department of Biochemistry, Faculty of Biological Sciences. During this period, she undertook the responsibilities of a supervisor or advisor for a considerable number of master's and PhD theses. Since 2022, she has held the position of associate professor. Her research interests are mainly focused on protein engineering, macromolecular interactions, structure-function relation, amyloidogenic proteins, Biotherapeutics, protein pathways and signaling cascades Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, FAIMBE, Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, moved to the University of California Santa Cruz. In 2004, joined the Indiana University−Purdue University Indianapolis as a Senior Research Professor. Since 2010, Professor Uversky is with USF, where he works on various aspects of protein intrinsic disorder phenomenon and on analysis of protein folding and misfolding processes. Prof. Uversky has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He is also serving as an editor in a number of scientific journals. He was a co-founder of the Intrinsically Disordered Proteins Subgroup at the Biophysical Society and the Intrinsically Disordered Proteins Gordon Research Conference. Prof. Uversky collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.

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