Overview

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.  It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.  Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

Full Product Details

9780470021408

Table of Contents

Reviews

?This is a fantastic collection of hERG channel-related papers, with discussion from experts in the field raising questions yet to be answered.? (The Biochemist, 1 December 2012) ?a useful reference for current literature and developments on the cardiac hERG potassium channel. No other books are currently available on the subject. (Doody's Health Services)

...a useful reference for current literature and developments on the cardiac hERG potassium channel. No other books are currently available on the subject. (Doody's Health Services)

!a useful reference for current literature and developments on the cardiac hERG potassium channel. No other books are currently available on the subject. (Doodya s Health Services)

Author Information

The Novartis Foundation is an international scientific and educational charity that promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

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