Overview

Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

Full Product Details

Author:   Kevin J. Mitchell (Trinity College Dublin)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Dimensions:   Width: 18.80cm , Height: 2.20cm , Length: 26.20cm
Weight:   0.789kg
ISBN:  

9781118524886

ISBN 10:   1118524888
Pages:   368
Publication Date:   25 September 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

List of Contributors vii Foreword Kevin J. Mitchell ix 1 The Genetic Architecture of Neurodevelopmental Disorders 1 Kevin J. Mitchell 2 Overlapping Etiology of Neurodevelopmental Disorders 29 Eric Kelleher and Aiden Corvin 3 The Mutational Spectrum of Neurodevelopmental Disorders 49 Nancy D. Merner, Patrick A. Dion, and Guy A. Rouleau 4 The Role of Genetic Interactions in Neurodevelopmental Disorders 69 Jason H. Moore and Kevin J. Mitchell 5 Developmental Instability, Mutation Load, and Neurodevelopmental Disorders 81 Ronald A. Yeo and Steven W. Gangestad 6 Environmental Factors and Gene–Environment Interactions 111 John McGrath 7 The Genetics of Brain Malformations 129 M. Chiara Manzini and Christopher A. Walsh 8 Disorders of Axon Guidance 155 Heike Blockus and Alain Chédotal 9 Synaptic Disorders 195 Catalina Betancur and Kevin J. Mitchell 10 Human Stem Cell Models of Neurodevelopmental Disorders 239 Peter Kirwan and Frederick J. Livesey 11 Animal Models for Neurodevelopmental Disorders 261 Hala Harony-Nicolas and Joseph D. Buxbaum 12 Cascading Genetic and Environmental Effects on Development: Implications for Intervention 275 Esha Massand and Annette Karmiloff-Smith 13 Human Genetics and Clinical Aspects of Neurodevelopmental Disorders 289 Gholson J. Lyon and Jason O'Rawe 14 Progress Toward Therapies and Interventions for Neurodevelopmental Disorders 319 Ayokunmi Ajetunmobi and Daniela Tropea Subject Index 345 Gene Index 353

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Author Information

Kevin J. Mitchell is an Associate Professor at the Smurfit Institute of Genetics and Institute of Neuroscience at Trinity College Dublin

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