Overview

The rapid developments in molecular genetics have clarified many of the muta­ tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method­ ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis­ ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup­ ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con­ cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin­ guished researchers from the United States, the United Kingdom, France, Ger­ many, Italy, and Japan were invited. Each presentation precipitated intense dis­ cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.

Full Product Details

Author:   T. Akamizu ,  M. Kasuga ,  T.F. Davies
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   Softcover reprint of the original 1st ed. 2002
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.367kg
ISBN:  

9784431680024

ISBN 10:   4431680020
Pages:   222
Publication Date:   20 November 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Autoimmune Thyroid Diseases.- Genetic dissection of familial autoimmune thyroid diseases using whole genome screening.- Genome screening for Graves' disease susceptibility loci in U.K. families.- The involvement of the HLA region in genetic susceptibility to Grave s' disease.- HLA and autoimmune thyroid diseases.- What can we learn from the genetics of diabetes?.- The genomic biology of the human chromosome 2q33 costimulatory receptor region.- CTLA-4 gene in the pathogenesis of Graves' disease.- The evolving role of CTLA-4 in the genetic predisposition to AITD.- Association of AITD with microsatellite markers for TSHR and CTLA-4 in Japanese patients.- 2 Familial Thyroid Cancers.- Familial non medullary thyroid cancer.- Cowden disease and the PTEN/MMACI gene.- Molecular mechanisms of RET activation in human neoplasia.- Lessons from Chernobyl; need for molecular epidemiology of childhood thyroid cancer.- Genetic events in radiation-induced thyroid cancer.- Keyword Index.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions