The G Protein-Coupled Receptors Handbook

Author:   Lakshmi A Devi
Publisher:   Springer
ISBN:  

9781603276276


Pages:   432
Publication Date:   15 September 2008
Format:   Undefined
Availability:   Out of stock   Availability explained


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The G Protein-Coupled Receptors Handbook


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Overview

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Full Product Details

Author:   Lakshmi A Devi
Publisher:   Springer
Imprint:   Springer
Dimensions:   Width: 22.90cm , Height: 2.40cm , Length: 15.20cm
Weight:   0.630kg
ISBN:  

9781603276276


ISBN 10:   1603276270
Pages:   432
Publication Date:   15 September 2008
Audience:   General/trade ,  General
Format:   Undefined
Publisher's Status:   Unknown
Availability:   Out of stock   Availability explained

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Reviews

. ..provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field. -TRENDS in Endocrinology and Metablosim


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