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OverviewA comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets. Full Product DetailsAuthor: Lakshmi A DeviPublisher: Springer Imprint: Springer Dimensions: Width: 22.90cm , Height: 2.40cm , Length: 15.20cm Weight: 0.630kg ISBN: 9781603276276ISBN 10: 1603276270 Pages: 432 Publication Date: 15 September 2008 Audience: General/trade , General Format: Undefined Publisher's Status: Unknown Availability: Out of stock ![]() Table of ContentsReviews. ..provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field. -TRENDS in Endocrinology and Metablosim Author InformationTab Content 6Author Website:Countries AvailableAll regions |