Overview

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Full Product Details

Author:   David P. Bazett-Jones ,  Graham Dellaire
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 2.70cm , Length: 23.50cm
Weight:   7.781kg
ISBN:  

9783319817682

ISBN 10:   331981768
Pages:   513
Publication Date:   23 June 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I - Nuclear Periphery.- 1.Laminopathies/Howard Worman.- Part II Nuclear Bodies.- 2.Nucleolus/Marie-Line Dubois and François-Michel Boisvert.- 3.Speckles/splicing and disease/Michael Ladomery and Sebastian Oltean.- 4.PML, cancer and stem cells/Julia P. Hofmann and Paolo Salomoni.- Part III Chromosomes.- 5.Chromosome territories/Karen J. Meaburn, Bharat Burman and Tom Misteli.- 6.Telomeres and Chromosome Instability/Tsz Wai Chu and Chantal Autexier.- PART IV Nuclear Domains and Development.- 7.Polycomb bodies/Vincenzo Pirrotta.- 8.Ikaros domains/Karen E. Brown.- PART V Nuclear Domains and Cell Stress.- 9.Senescence/SAHFs/Tamir Chandra.- 10.DNA repair foci as facultative nuclear domains/Michael J. Hendzel and Hilmar Strickfaden.- 11.DNA damage and the nucleus/Jordan Pinder, Anastazja Grabarz, Evi Soutoglou and Graham Dellaire.- 12.Inflammation and the nucleus/Sona Hubackova , Simona Moravcova and Zdenek Hodny.- 13.Viral infection and the nucleus/Lori Frappier.- PART VI Macromoleculardynamics within the nucleus.- 14.Actin filaments/motors/Guillaume Huet and Maria K. Vartiainen.- 15.Molecular diffusion/Alexander Gansen and Jörg Langowski.- PART VII Chromatin transactions and epigenetics.- 16.Fibres/interactions/Christopher J.F. Cameron, James Fraser, Mathieu Blanchette, and Josée Dostie.- 17.DNA replication     Sebastian Müller, Dan Filipescu and Geneviève Almouzni.- 18.Development and Epigenetics    Nuphar Salts and Eran Meshorer.- 19.Epigenetics and disease/Sanaa Choufani and Rosanna Weksberg.- PART VIII Transcription and RNA metabolism.- 20.Transcription factories/Christopher Eskiw and Jenifer Mitchell.- 21.RNA transport    Jonathan Sheinberger and Yaron Shav-Tal.  

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Author Information

David P. Bazett-JonesThe Hospital for Sick Children, Toronto, ON, Canada                  Graham DellaireDalhousie University, Halifax, NS, Canada

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