The Extracellular Matrix: an Overview
Author:   Robert Mecham
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   2011 ed.
ISBN:  

9783642267192


Pages:   426
Publication Date:   21 April 2013
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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The Extracellular Matrix: an Overview


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Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Full Product Details

Author:   Robert Mecham
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2011 ed.
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   0.670kg
ISBN:  

9783642267192


ISBN 10:   364226719
Pages:   426
Publication Date:   21 April 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

An overview of extracellular matrix structure and function.-  Fibronectin and other adhesive glycoproteins.-  Collagen: suprastructures and collagen fibril assembly.-  Asement membrane; Hyaluronan and the Aggregating Proteoglycans.- The small, leucine-rich proteoglycans.- Microfibrils and fibrillin.- Elastin.- Lysyl oxidase and lysyl oxidase-like enzymes.- The Fibulins.- Matricellular proteins.

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