Overview

High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Full Product Details

Author:   Stuart MacNeill
Publisher:   Springer
Imprint:   Springer
Edition:   2012 ed.
Volume:   62
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   0.740kg
ISBN:  

9789400745711

ISBN 10:   9400745710
Pages:   348
Publication Date:   24 August 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Composition and dynamics of the eukaryotic replisome: a brief overview. - 2. Evolutionary diversification of eukaryotic DNA replication machinery. - 3. The origin recognition complex: a biochemical and structural view. - 4. Archaeal Orc1/Cdc6 Proteins. -5. Cdt1 and Geminin in DNA replication initiation. - 6. MCM structure and mechanics: what we have learned from archaeal MCM. - 7. The Eukaryotic Mcm2-7 Replicative Helicase. - 8. The GINS complex: structure and function. - 9. The Pol α-primase complex. - 10. The structure and function of replication protein A in DNA replication. - 11. Structural biology of replication initiation factor Mcm10. - 12. Structure and function of eukaryotic DNA polymerase d. - 13. DNA polymerase ε. - 14. The RFC clamp loader: structure and function. - 15. PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. - 16. The wonders of Flap Endonucleases: structure, function, mechanism and regulation. - 17.  DNA ligase I, the replicative DNA ligase

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