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Author:   Stuart MacNeill
Publisher:   Springer
Imprint:   Springer
Edition:   2012 ed.
Volume:   62
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.545kg
ISBN:  

9789400797703

ISBN 10:   9400797702
Pages:   348
Publication Date:   21 September 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Composition and dynamics of the eukaryotic replisome: a brief overview. - 2. Evolutionary diversification of eukaryotic DNA replication machinery. - 3. The origin recognition complex: a biochemical and structural view. - 4. Archaeal Orc1/Cdc6 Proteins. -5. Cdt1 and Geminin in DNA replication initiation. - 6. MCM structure and mechanics: what we have learned from archaeal MCM. - 7. The Eukaryotic Mcm2-7 Replicative Helicase. - 8. The GINS complex: structure and function. - 9. The Pol α-primase complex. - 10. The structure and function of replication protein A in DNA replication. - 11. Structural biology of replication initiation factor Mcm10. - 12. Structure and function of eukaryotic DNA polymerase d. - 13. DNA polymerase ε. - 14. The RFC clamp loader: structure and function. - 15. PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. - 16. The wonders of Flap Endonucleases: structure, function, mechanism and regulation. - 17.  DNA ligase I, the replicative DNA ligase

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