The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic
Author:   Johann H. Mulzer ,  A. Douglas Kinghorn ,  Karl-Heinz Altmann ,  Gerhard Höfle
Publisher:   Springer Verlag GmbH
Edition:   2009 ed.
Volume:   90
ISBN:  

9783211782064


Pages:   260
Publication Date:   22 December 2008
Format:   Hardback
Availability:   Out of stock   Availability explained
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The Epothilones: An Outstanding Family of Anti-Tumor Agents: From Soil to the Clinic


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Overview

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.

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Author:   Johann H. Mulzer ,  A. Douglas Kinghorn ,  Karl-Heinz Altmann ,  Gerhard Höfle
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   2009 ed.
Volume:   90
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.576kg
ISBN:  

9783211782064


ISBN 10:   3211782060
Pages:   260
Publication Date:   22 December 2008
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

General Aspects.- Biosynthesis and Heterologous Production of Epothilones.- Total Synthesis of Epothilones A-F.- Semisynthetic Derivatives of Epothilones.- Preclinical Pharmacology and Structure-Activity Studies of Epothilones.- Clinical Studies with Epothilones.

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