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Author:   Trevor G. Cooper
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Weight:   0.610kg
ISBN:  

9783540169284

ISBN 10:   3540169288
Pages:   296
Publication Date:   01 October 1986
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

I. Maturation of Spermatozoa in the Epididymis.- 1. Acquisition in the Epididymis of Sperm Fertilising Ability.- 2. Involvement of the Epididymis in the Development of Sperm Fertilising Ability.- 3. The Nature of the Androgen-Dependent Epididymal Secretions Involved.- 4. Response of Immature Spermatozoa to Epididymal Secretions.- 5. Scope of this Review.- 6. Summary.- 7. References.- II. Fertilisation.- A. Sperm Motility.- 1. The Need for Flagellar Activity of Sperm for Them to Reach the Egg.- 2. The Ability of Immature Spermatozoa to Reach the Site of Fertilisation.- 3. Development in the Epididymis of Sperm Motility In-Vitro.- 4. The Nature of the Reduced Motility of Immature Spermatozoa.- 5. Involvement of the Epididymis in the Maturation of Motility.- 6. Induction of Motility in Immature Spermatozoa In-Vitro.- 7. Relationship of Induced Forward Motility to Fertilising Ability.- 8. Summary.- 9. References.- B. Capacitation.- 1. Detection of Capacitation.- 2. Changes in the Sperm Surface During Capacitation.- 3. Mechanisms of Capacitation.- 4. Consequences for Membrane Fluidity.- 5. Action of Decapacitation Factors.- 6. Maintenance of Motility.- 7. Requirements of Capacitation.- 8. Development in the Epididymis of the Ability of Spermatozoa to be Capacitated.- 9. Involvement of the Epididymis in Permitting Capacitation.- 10. Summary.- 11. References.- C. Consequences of Capacitation. I. Sperm-Egg Binding.- 1. Sperm-Egg Binding.- 2. Relationship to Capacitation.- 3. Relationship to the Acrosome Reaction.- 4. Mechanisms of Binding.- 5. Development in the Epididymis of the Ability of Sperm to Bind to Eggs.- 6. Involvement of the Epididymis in the Development of the Sperm Surface.- 7. Summary.- 8. References.- D. Consequences of Capacitation. II. The Acrosome Reaction.- 1. The Acrosome Reaction.- 2. Mechanism of the Acrosome Reaction.- 3. Requirements for the Acrosome Reaction.- 4. Stimulus to the Acrosome Reaction.- 5. Relationship to Capacitation.- 6. Relationship to Hyperactivated Motility.- 7. Relationship to Fertilisation.- 8. Site of the Acrosome Reaction.- 9. Consequences of the Acrosome Reaction.- 10. Development in the Epididymis of the Ability of Spermatozoa to Undergo the Acrosome Reaction.- 11. Involvement of the Epididymis in Permitting the Acrosome Reaction.- 12. Summary.- 13. References.- E. Consequences of Capacitation. III. Hyperactivation.- 1. Hyperactivation.- 2. Requirements of Hyperactivated Motility.- 3. Mechanisms of Hyperactivated Motility.- 4. Stimulus to Hyperactivated Motility.- 5. Relationship to Capacitation.- 6. Relationship to the Acrosome Reaction.- 7. Relationship to Fertilisation.- 8. Site of Hyperactivated Motility.- 9. Consequences of Hyperactivated Motility.- 10. Development in the Epididymis of the Ability of Sperm to Display Hyperactivated Motility.- 11. Involvement of the Epididymis in Permitting Hyperactivation.- 12. Summary.- 13. References.- F. Sperm-Egg Fusion.- 1. Binding to the Vitellus.- 2. Fusion with the Vitellus.- 3. Relationship to Capacitation.- 4. Relationship to the Acrosome Reaction.- 5. Relationship to Sperm Motility.- 6. Regions of the Sperm Head Involved in Fusion.- 7. Basis of Fusion.- 8. Development in the Epididymis of the Ability of Sperm to Fuse with Eggs.- 9. Involvement of the Epididymis in Permitting Sperm-Egg Fusion.- 10. Summary.- 11. References.- G. Post-Fusion Events.- 1. Activation of the Eggs.- 2. Decondensation of Sperm Chromatin.- 3. Formation of the Male Pronucleus.- 4. Chromosome Condensation.- 5. Development in the Epididymis of the Ability of Sperm to Interact with the Vitellus.- 6. Involvement of the Epididymis in Permitting Post-Fusion Events.- 7. Summary.- 8. References.- III. Function of the Epididymis and Its Secretory Products.- A. Epididymal Structure and Function.- 1. Introduction.- 2. Epididymal Structure.- 3. Blood Supply.- 4. Lymphatics.- 5. Methods of Study.- 6. Epithelial Cells.- 7. Testicular Control of Epididymal Function.- 8. Permeability of the Epididymal Epithelium.- 9. Resorptive Activity of the Epididymis.- 10. Secretory Activity of the Epididymis.- 11. Summary.- 12. References.- B. Secretion of Steroids by the Epididymis.- 1. Steroids in Epididymal Tissue.- 2. Origin of Epididymal Steroids.- 3. Testicular Control of Androgenic Function in the Epididymis.- 4. Endocrine Role of the Epididymis.- 5. Role of Steroids in Epididymal Function.- 6. Interactions of Steroids with Spermatozoa.- 7. Role of Steroids in Spermatozoal Function.- 8. Summary.- 9. References.- C. Resorption and Secretion of Ions by the Epididymis.- 1. Luminal Contents.- 2. Transporting Activities.- 3. Control of Transporting Activities.- 4. Role of Monovalent and Divalent Cations.- 5. Interactions of Ions with Maturing Spermatozoa.- 6. ATPase Activity in Spermatozoa.- 7. Polycations.- 8. Summary.- 9. References.- D. Epididymal Secretion of Glycerophosphocholine (GPC).- 1. Concentration in Epididymal Tissue.- 2. Origin of Epididymal GPC.- 3. Androgen Dependence.- 4. Role of GPC in Epididymal Function.- 5. Summary.- 6. References.- E. Epididymal Secretion of Carnitine.- 1. Concentration in Epididymal Tissue.- 2. Origin of Epididymal Carnitine.- 3. Androgen Dependence.- 4. Interaction of Carnitine with Maturing Spermatozoa.- 5. Roles of Carnitine in Epididymal Function.- 6. Summary.- 7. References.- F. Epididymal Secretion of myo-Inositol.- 1. Concentration in Epididymal Tissue.- 2. Origin of Epididymal Inositol.- 3. Androgen Dependence.- 4. Metabolism of Inositol.- 5. Interaction of Inositol with Maturing Spermatozoa.- 6. Role of Inositol in Epididymal Function.- 7. Summary.- 8. References.- G. Epididymal Secretion and Resorption of Proteins.- 1. Luminal Proteins.- 2. Origin of Epididymal Proteins.- 3. Protein Synthesis and Precursors in the Epididymis.- 4. Protein Secretion in the Epididymis.- 5. Androgen Dependence.- 6. Control of Protein Synthesis by Luminal Fluid.- 7. Site of Synthesis of Specific Proteins.- 8. Evidence for Interactions of Luminal Proteins with Spermatozoa.- 9. Binding of Proteins to Maturing Spermatozoa.- 10. The Nature of the Interaction.- 11. Site of Binding.- 12. Role of Proteins in Epididymal Function.- 13. Peptides.- 14. Resorption of Proteins by the Epididymis.- 15. Summary.- 16. References.- IV. Conclusions.- 1. The Importance of the Epididymis in Male Fertility.- 2. Summary.- Appendix I (Tables 1-21).- Appendix II (Figures 1-8).

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