Overview

This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics.  Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression.  Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use.  This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems.   This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Full Product Details

Author:   Wu-Min Deng
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Volume:   1167
Weight:   0.591kg
ISBN:  

9783030236311

ISBN 10:   3030236315
Pages:   250
Publication Date:   26 September 2020
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Prelims 1.      Drosophila model in cancer: an introduction   2.      Using Drosophila models and tools to understand the mechanisms of novel human cancer driver gene function 3.      The initial stage of tumorigenesis in Drosophila epithelial tissuesi   4.      Drosophila models of cell polarity and cell competition in tumourigenesis 5.      Two sides of the same coin – compensatory proliferation in regeneration and cancer 6.      P53 and apoptosis in the Drosophila model   7.      Autophagy and tumorigenesis in Drosophila 8.      Filling the gaps among obesity, the CDK8 module, and uterine tumors using Drosophila 9.      MicroRNAs in Drosophila cancer models 10.  Cancer Stem Cells and Stem Cell Tumors in Drosophila 11.  Drosophila as a model for tumor-induced organ wasting  12.  Drosophila melanogaster as a model system for human glioblastomas 13.  What Drosophila Can Teach Us About Radiation Biology of Human Cancers 14.  A Drosophila based cancer drug discovery frameworkIn Index.

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Author Information

Wu-Min Deng is a Professor at the Department of Biological Sciences in Florida State University.

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