Discovery and Utility of Chemical Probes in Target Discovery
Author:   Paul Brennan (University of Oxford, UK) ,  Saleta Vazquez Rodriguez (University of Oxford, UK) ,  Gennady Poda ,  Nir London
Publisher:   Royal Society of Chemistry
Volume:   Volume 16
ISBN:  

9781788015899


Pages:   342
Publication Date:   26 November 2020
Format:   Hardback
Availability:   In Print   Availability explained
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Discovery and Utility of Chemical Probes in Target Discovery


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Overview

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

Full Product Details

Author:   Paul Brennan (University of Oxford, UK) ,  Saleta Vazquez Rodriguez (University of Oxford, UK) ,  Gennady Poda ,  Nir London
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 16
Weight:   0.672kg
ISBN:  

9781788015899


ISBN 10:   1788015894
Pages:   342
Publication Date:   26 November 2020
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Introduction to Chemical Probes; DNA-Encoded Chemistry and its use to Discover Chemical Probes; Computational Methods for the Discovery of Chemical Probes; Best Practices for Design and Characterization of Covalent Chemical Probes; Cyclic Peptides as Chemical Probes; Discovery and Use of Natural Products and Derivatives as Chemical Probes; Targeted Protein Degradation Chemical Probes; Chemical Probes for Kinases; Chemical Probes to Control RNA Function; Assays to Characterize Cellular Pharmacology of a Chemical Probe; Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegeneration

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