Overview

Cytoskeleton research spans a broad range of scientific disciplines. This book provides an introduction to the subject for those requiring a basic knowlege of cytoskeletal structure, especially with respect to its functional aspects, from the swimming of spermatozoa to the crawling of cultured cells; from the transport of vesicles and organelles along nerve axons to the orderly segregation of chromosomes at mitosis and meiosis. This volume is written for advanced undergraduate and postgraduate students in cell bioloogy, molecular biology and biochemistry.

Full Product Details

Author:   Terence M. Preston ,  C.A. King ,  S. Hyams
Publisher:   Kluwer Academic Publishers Group
Imprint:   Kluwer Academic Publishers
Edition:   1990 ed.
Dimensions:   Width: 14.80cm , Height: 1.20cm , Length: 21.00cm
Weight:   0.288kg
ISBN:  

9780216926745

ISBN 10:   0216926742
Pages:   202
Publication Date:   01 April 1990
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1 Introduction.- 2 The Molecular Components of the Cytoskeleton.- 2.1 Actin and actin-associated proteins.- 2.1.1 Actin filaments can be detected in individual cells.- 2.1.2 Biochemistry of actin.- 2.1.3 Actin-binding proteins (ABPs).- 2.1.4 Biophysical properties of actin solutions.- 2.1.5 Myosin/actin interactions and force generation.- 2.2 Microtubules and microtubule-associated proteins.- 2.2.1 Organisation of microtubules in cells.- 2.2.2 Properties of tubulin.- 2.2.3 Microtubule assembly in vitro.- 2.2.4 Microtubule dynamics in vivo.- 2.2.5 Microtubule-associated proteins.- 2.2.6 Microtubule-associated proteins and cell motility.- 2.3 Intermediate filaments.- 2.3.1 Structure.- 2.3.2 Formation of networks within the cytoplasm.- 2.3.3 Nuclear lamins.- 2.3.4 Tektins.- 2.3.5 Intermediate filament-associated proteins (IFAPs).- 2.3.6 Control of intermediate filament assembly.- 2.3.7 An intracellular function for intermediate filaments?.- 2.3.8 The use of antibodies to intermediate filament proteins in tissue typing.- 2.4 Summary.- 3 Movement within Cells.- 3.1 Axonal transport.- 3.2 Intracellular motility in the Protozoa.- 3.2.1 Reticulomyxa.- 3.2.2 Allogromia.- 3.3 Cytoplasmic transport in the ovaries of hemipteran insects.- 3.4 Movement of pigment granules in chromatophores.- 3.5 Cytoplasmic streaming in plant cells.- 3.6 Summary.- 4 Mitosis.- 4.1 Basic steps of mitosis.- 4.2 The mitotic spindle: general properties and design principles.- 4.3 Organisation of spindle microtubules.- 4.3.1 Polarity of spindle microtubules.- 4.3.2 Sites of tubulin addition and loss in the spindle.- 4.4 Mechanisms of anaphase chromosome movement.- 4.4.1 Anaphase A.- 4.4.2 Anaphase B.- 4.5 Summary and conclusions.- 5 Cilia and Flagella.- 5.1 Distribution and waveforms.- 5.2 Basal bodies and rootlets.- 5.2.1 Basal body formation.- 5.2.2 Basal body nucleic acid?.- 5.2.3 Basal body function.- 5.2.4 Rootlets.- 5.3 Structure of the axoneme.- 5.3.1 Variants of flagellar structure.- 5.3.2 Variant axonemes.- 5.4 Extra-axonemal components.- 5.5 Membrane specialisations.- 5.6 Biochemical complexity of the axoneme.- 5.7 The sliding microtubule model.- 5.7.1 Control of microtubule sliding.- 5.7.2 Function and structure of the two dynein arms.- 5.7.3 Conversion of sliding into bending.- 5.8 Behavioural responses of microorganisms and the control of ciliary and flagellar beating.- 5.8.1 The avoiding response of Paramecium.- 5.8.2 Responses of Chlamydomonas to light.- 5.8.3 Other calcium-induced responses of ciliated and flagellated cells.- 6 Crawling Movements.- 6.1 Common features of crawling locomotion.- 6.1.1 Traction.- 6.1.2 Force production.- 6.1.3 Polarity.- 6.2 Amoeboid movement.- 6.2.1 General account.- 6.2.2 Actin microfilaments can be detected in living amoebae.- 6.2.3 Biochemical approaches.- 6.2.4 Cell-substratum interactions.- 6.3 Chemotaxis.- 6.3.1 General account.- 6.3.2 Chemotaxis in Dictyostelium.- 6.4 Tissue cell locomotion.- 6.4.1 Fibroblast locomotion.- 6.4.2 Nerve growth cone.- 6.5 Myosin and crawling locomotion.- 7 Cell Surface Motility.- 7.1 General account.- 7.2 Gliding.- 7.2.1 Gliding in Chlamydomonas.- 7.2.2 Gliding in sporozoan Protozoons.- 7.3 Summary.- 8 Other Mechanisms for Producing Force and Movements.- 8.1 Contractile phenomena.- 8.1.1 Peritrich stalk.- 8.1.2 Myonemes.- 8.1.3 Basal body rootlets of algae.- 8.2 Crawling in nematode sperm.- Further Reading.

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