Overview

The transformation of a normal cell into a cancer cell is not a sudden but a slow continuous process which may take years. A systematic study of the morphological and structural changes that take place during this cellular transformation has only become possible since methods were developed to induce a high incidence of tumors in experimental animals. The growth of such tumors can be followed during all stages of their development. For several reasons, rat liver has proved to be particularly suitable. For more than thirty years it has been known that one can induce tumors in rat liver experimentally with many different substances. The azo dyes which were used originally (YOSHIDA, 1932; KINOSITA, 1937) have since been replaced by more potent carcinogens. The recently discovered nitrosamines, dimethylnitrosamine (MAGEE and BARNES, 1956), diethylnitrosamine (SCHMAHL et aI. , 1960) and N-nitrosomorpholine (DRUCKREY et aI. , 1961) should be mentioned in this context. Used in the proper dose, these carcinogens lead within a few months to the formation of multicentric hepatomas in practically 100 Ufo of the experimental animals, and are therefore a very useful tool for studies of the cytogenesis of cancer (see BUCHNER, 1961; GRUND­ MANN, 1961; GRUNDMANN and SIEBURG, 1962; OEHLERT and HARTJE, 1963; BAN­ NASCH and MULLER, 1964). The liver parenchyma as such offers a very big technical advantage because it consists of a rather homogenous cell population.

Full Product Details

Author:   Peter Bannasch ,  A. Schimpl
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1968
Volume:   19
Dimensions:   Width: 17.00cm , Height: 0.60cm , Length: 24.40cm
Weight:   0.222kg
ISBN:  

9783642884016

ISBN 10:   3642884016
Pages:   108
Publication Date:   21 March 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

A. Introduction.- B. Material and Methods.- I. Animal Experiments.- II. Techniques of Light Microscopy.- III. Techniques of Electron Microscopy.- C. Results.- I. The Precancerous Phase.- 1. The Acinuscentral Cytotoxic Pattern.- a) Light Microscopy.- b) Electron Microscopy.- 2. The Acinusperipheral Cytotoxic Pattern.- a) Light Microscopy.- b) Electron Microscopy.- II. The Transformation into Hepatomas.- a) Light Microscopy.- b) Electron Microscopy.- D. Discussion.- I. Dose-dependence and Significance of the Acinuscentral and the Acinusperipheral Cytotoxic Pattern.- 1. Acinuscentral Cytotoxic Pattern.- 2. Acinusperipheral Cytotoxic Pattern.- II. The Fate of the Individual Cytoplasmic Componente during Carcinogenesis.- 1. The Mitochondria.- 2. Glycogen.- 3. The Granular Endoplasmic Reticulum (Ergastoplasm).- 4. The Agranular Endoplasmic Reticulum.- III. The Transformation of Glycogen Storage Cells into Hepatoma Cells.- E. Summary.- References.

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