Overview

Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per­ ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation­ ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ­ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

Full Product Details

Author:   Stuart G. Siddell
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1995
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   0.670kg
ISBN:  

9781489915337

ISBN 10:   1489915338
Pages:   418
Publication Date:   22 June 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 The Coronaviridae: An Introduction.- 2 Coronavirus Replication, Transcription, and RNA Recombination.- 3 Coronavirus Gene Expression: Genome Organization and Protein Synthesis.- 4 Coronavirus Receptors.- 5 The Coronavirus Surface Glycoprotein.- 6 The Coronavirus Membrane Glycoprotein.- 7 The Coronavirus Nucleocapsid Protein.- 8 The Coronavirus Hemagglutinin Esterase Glycoprotein.- 9 The Small-Membrane Protein.- 10 The Coronavirus Nonstructural Proteins.- 11 The Molecular Biology of Toroviruses.- 12 The Coronaviruslike Superfamily.- 13 Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses.- 14 Feline Infectious Peritonitis.- 15 Epidemiology of Infectious Bronchitis Virus.- 16 Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology.- 17 Pathogenesis of the Porcine Coronaviruses.- 18 Human Coronavirus Infections.- 19 The Pathogenesis of Torovirus Infections in Animals and Humans.

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