Overview

The complement system plays a key role in host defense functions and inflammatory reactions. This book provides the present state-of-the-art of the theoretical fundamentals and basic biochemical features of the complement system, its activation and regulation. The biological functions are also discussed in the context of more complex conditions, e.g. host defense, chronic inflammation and graft rejection. This is a thorough revision of the 1988 edition, with additional chapters addressing the progress made in the understanding of the interconnection of the complement system and other mediator systems, especially with cellular receptors. The immunopathology section has been expanded, and a chapter on diagnostic procedures and their interpretation has been added.

Full Product Details

Author:   K. Rother ,  Gerd O. Till ,  Gertrud M. Hänsch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2nd rev. ed. 1998
Dimensions:   Width: 15.50cm , Height: 3.10cm , Length: 23.50cm
Weight:   2.200kg
ISBN:  

9783540618942

ISBN 10:   3540618945
Pages:   564
Publication Date:   18 November 1997
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Components and Reactivity.- 1.1 Components.- 1.2 Reactivity.- 1.3 Surface Receptors and Signaling Pathways.- 2 Biologic Functions.- 2.1 Complement in the Induction of Antibody Response.- 2.2 Maintenance of Immune Complex Solubility and Immune Adherence.- 2.3 Interaction with Effector Cells.- 2.4 Host Defense Against Infection.- 2.5 Possible Role of Complement Regulators in Reproduction.- 2.6 Network Interactions of the Complement System with Other Serum Mediator Systems.- 3 Pathology.- 3.1 Complement Deficiencies in Animals: Impact on Biological Functions.- 3.2 Complement Deficiencies in Humans.- 3.3 C3 Nephritic Factor.- 3.4 Complement in Inflammation.- 3.5 Role of Complement in Graft Rejection.- 3.6 Complement Activation on Artificial Surfaces in Biomedical Therapies.- 3.7 Adverse Reactions to Drugs.- 4 Complement Manipulation In Vivo.- 5 The Clinical Laboratory: Testing the Complement System.

Reviews

"From the reviews of the first edition: ""Overall, the volume is a most useful resource on complement and will be of tremendous value for investigators in the area of complementology, newcomers in the field, and instructors for updating their information on the subject."" ASM News - American Society for Microbiology"

From the reviews of the first edition: <br> Overall, the volume is a most useful resource on complement and will be of tremendous value for investigators in the area of complementology, newcomers in the field, and instructors for updating their information on the subject. ASM News - American Society for Microbiology

From the reviews of the first edition: Overall, the volume is a most useful resource on complement and will be of tremendous value for investigators in the area of complementology, newcomers in the field, and instructors for updating their information on the subject. ASM News - American Society for Microbiology

From the reviews of the first edition: Overall, the volume is a most useful resource on complement and will be of tremendous value for investigators in the area of complementology, newcomers in the field, and instructors for updating their information on the subject. ASM News - American Society for Microbiology

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