Overview

Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described.

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9780081010334

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Further to his superannuation as Dy. Director for the Central Drug Research Institute, Lucknow, UP, India, a world class, premier research Institute for drug development, Prof Ram became Emeritus professor and served various academic institutions for 10 years. Besides research experience, he has also earned 18 years of experience teaching heterocyclic chemistry to graduate and post-graduate classes. He has 256 publications to his name, including several review articles published in top chemistry journals. He is also recipient of prestigious fellowships from JSPS, Japan, Alexander von Humboldt (AvH), Germany and NIH, USA. Prof Sethi has over 27 years of experience teaching graduate and post-graduate classes. He has written three popular text books on Practical chemistry as well as Basic Organic chemistry for graduate and postgraduate students. In addition, he has produced numerous research publications and review articles. Prof Nath has over 10 years of teaching experience of graduate and postgraduate classes in the Department of Chemistry, Delhi University. He has been abroad as a postdoctoral fellow in Canada and USA for several years working on heterocyclic systems. At present, his research is also focused on the development of various heterocyclic systems including porphyrins and biomimetic metalloporphyrins. He has numerous publications and review articles. Prof. Ramendra Pratap completed his master’s from the University of Gorakhpur in 2001 and then he moved to Central Drug Research Institute, Lucknow for doctoral research. He worked with Dr. Vishnu Ji Ram for four and a half years on ring transformation reactions of 2H-pyran-2-ones. He worked on nucleoside modification chemistry as a postdoctoral fellow at the City University of New York, USA, for two years. He received a renowned Humboldt fellowship and shifted to the University of Saarland, Germany. In Saarbrucken, he was involved in Mo-catalyzed reactions. In September 2010, He joined the Department of Chemistry, University of Delhi as an Assistant Professor. Currently, He is working as a full Professor. Till now he has published more than 100 research papers in various international Journals. He also received JSPS invitation fellowship during the year 2016-17. His chemistry focuses on developing various heterocycles, carbocycles, materials, and metal-catalyzed bond formation reactions. His major research contribution involves use of isolated and fused pyranones to establish new molecular entities.

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