Overview

The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advance has been made on our understanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in details the DNA and protein components of this structure, and their individual functions, in species as diverse as budding and fission yeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling ""passenger"" proteins; important emerging concepts such as latest centromeres and epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application of centromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject

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9780198577805

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Reviews

<br> The writing is concise and very clear. The intent of the book was to address the needs of both the beginning and advanced reader, and Choo has accomplished his goal nicely. The diagrams and illustrations are excellent, as are the graphs and tables. . . . I recommend this book highly to the student of centromeres . . . I am aware of no other text where this information can be found in such elegant detail. --Journal of the Association of Genetic Technologists<br> Although this is clearly an excellent reference work for the specialist, it is sufficiently simply explained that it would also be good for non-specialists and students. --SGM Quarterly<br> Specialty books sometimes serve a very small audience because they are too technical for the general audience and out of date for the specialist. This book is an exception. The author focuses on the recent success stories in identifying the molecular nature of the centromere in yeast, and complements this story with an interesting and in

The writing is concise and very clear. The intent of the book was to address the needs of both the beginning and advanced reader, and Choo has accomplished his goal nicely. The diagrams and illustrations are excellent, as are the graphs and tables. . . . I recommend this book highly to the student of centromeres . . . I am aware of no other text where this information can be found in such elegant detail. --Journal of the Association of Genetic Technologists Although this is clearly an excellent reference work for the specialist, it is sufficiently simply explained that it would also be good for non-specialists and students. --SGM Quarterly Specialty books sometimes serve a very small audience because they are too technical for the general audience and out of date for the specialist. This book is an exception. The author focuses on the recent success stories in identifying the molecular nature of the centromere in yeast, and complements this story with an interesting and informative review of the status of our knowledge of centromere structure in 'higher' eukaryotes. . . . The author provides a thorough analysis of information on centromere function, effect of centromere on the genes in adjoining chromosomal regions, and the interrelationships between centromere duplication and mitotic checkpoints. The interaction between the cell cycle machinery of the cell and the function of centromeric proteins are clearly presented. . . . Overall, I highly recommend this book for anyone who wants a thorough and clear update (to 1997) of centromere structure and function. --The Quarterly Review of Biology

The writing is concise and very clear. The intent of the book was to address the needs of both the beginning and advanced reader, and Choo has accomplished his goal nicely. The diagrams and illustrations are excellent, as are the graphs and tables. . . . I recommend this book highly to the student of centromeres . . . I am aware of no other text where this information can be found in such elegant detail. --Journal of the Association of Genetic Technologists<br> Although this is clearly an excellent reference work for the specialist, it is sufficiently simply explained that it would also be good for non-specialists and students. --SGM Quarterly<br> Specialty books sometimes serve a very small audience because they are too technical for the general audience and out of date for the specialist. This book is an exception. The author focuses on the recent success stories in identifying the molecular nature of the centromere in yeast, and complements this story with an interesting and informative review of the status of our knowledge of centromere structure in 'higher' eukaryotes. . . . The author provides a thorough analysis of information on centromere function, effect of centromere on the genes in adjoining chromosomal regions, and the interrelationships between centromere duplication and mitotic checkpoints. The interaction between the cell cycle machinery of the cell and the function of centromeric proteins are clearly presented. . . . Overall, I highly recommend this book for anyone who wants a thorough and clear update (to 1997) of centromere structure and function. --The Quarterly Review of Biology<br>

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