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Author:   Ibra S. Fancher (Assistant Professor, Department of Kinesiology and Applied Physiology, University of Delaware, College of Health Sciences, DE, USA) ,  Andreia Z. Chignalia (Assistant Professor, Department of Anesthesiology, University of Arizona, College of Medicine-Tucson, Arizona, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443191596

ISBN 10:   044319159
Pages:   166
Publication Date:   11 April 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Impairment of endothelial glycocalyx in atherosclerosis and obesity Sang Joon Ahn, Elizabeth Le Master, Sara T. Granados and Irena Levitan 2. The glycocalyx and calcium dynamics in endothelial cells Cameron M. Mortazavi, Jillian M. Hoyt, Aamir Patel and Andreia Z. Chignalia 3. Mechanotransduction and the endothelial glycocalyx: Interactions with membrane and cytoskeletal proteins to transduce force Hassan Askari, Masoumeh Sadeghinejad and Ibra S. Fancher 4. Setting the stage for universal pharmacological targeting of the glycocalyx Karim Almahayni and Leonhard Möckl 5. The effects of female sexual hormones on the endothelial glycocalyx Simone R. Potje, Núbia S. Martins, Maira N. Benatti, Daniel Rodrigues, Vânia L. D. Bonato and Rita C. Tostes 6. The role of hyaluronan in endothelial glycocalyx and potential preventative lifestyle strategy with advancing age Jisok Lim, Daniel R. Machin and Anthony J. Donato

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Author Information

Dr. Fancher is an Assistant Professor at the University of Delaware in the Department of Kinesiology and Applied Physiology, College of Health Sciences. Dr. Fancher’s immediate interests are in understanding how cardiovascular risk factors, such as obesity, impair vascular endothelial ion channel function which ultimately results in dysregulation of vascular function. His recent studies have detailed a link between damage to the endothelial glycocalyx and impaired K+ channel function in obesity; a mechanism he proposes contributes to obesity-induced vascular dysfunction. Ongoing studies in the lab are focused on determining the mechanistic link between elevated macronutrients associated with a poor Western diet and obesity, disruption of the glycocalyx, and K+ channel function. Dr. Andreia Z. Chignalia is an Assistant Professor at the University of Arizona, Department of Anesthesiology, College of Medicine-Tucson. The research in the Chignalia lab focuses on studying the redox mechanisms underlying cardiovascular diseases and associated pulmonary complications. Special emphasis is given to explore the differential redox-sensitive pathways activated by individual glycocalyx components during disease progression. Her research program utilizes a broad range of techniques that span from in vitro, in situ, and in vivo animal models of disease with a translational approach to advance the understanding of human disease with the goal to identify new targets for drug development.

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