Overview

Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations. Key Features It reconstructs accurately the cytoarchitecture and morphofunctional relationships between the elements of the central nervous (brain) and genitourinary (urinary bladder system). Offers for the first time a both quantitative and qualitative, assessment of the neurohormonal and mechanobiological processes involved in the process. Provides a comprehensive description for intertwined regulatory pathways in terms of spatiotemporal dynamic representations. Encourages the reader to develop and apply a unique holistic approach to solving complex biomedical problems in the area of growth and remodeling of the urinary bladder through application of modern methods of computational biology.

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9780750335652

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Reviews

System computational biology is the intersection of computer science, biology and big data to understand many cellular processes in the biological system and its relationship. In this case, this book used an integrative approach to deciphering gene regulation to tissue growth and remodelling. The authors have been very detailed in explaining every material in the book. They always present the latest findings and relevant facts in each chapter. In addition, the mathematical equations used in this book make sense and are easy to understand, especially for unexpert readers. The important point thatmakes this book very interesting is, the author has succeeded in explaining biological systems with mathematical models, and even managed to describe the schematic models superbly. However, most of the presumptionsmade in themodel are basedon the conclusionprocess and guestimates with only a few confirmable facts. As such, the models themselves need to be continually refined and improved to make them more accurate and reliable in line with recent technological advances and ever-changing ways of perceiving life. Aras Beauty and Afnan Taqiyarrahman, CONTEMPORARY PHYSICS, December 2022 * CONTEMPORARY PHYSICS *

Author Information

Prof. Dr. R.N. Miftahoft is a Professor Emeritus of applied mathematics and medicine. He is internationally acclaimed as a leading scientist in the field of computational systems biology. He has authored and co-authored seven books in the field. Prof. Dr-Ing. C..J. Cyron is a Full Professor at Hamburg University of Technology and has actively participated in the organization of a host of conferences, workshops and summer schools on biomechanics and mechanobiology over a number of years.

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