Overview

The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.

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9781615047390

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The Cerebral Circulation has been an excellent source of information on the structure and function of blood vessels of the brain for graduate students, medical students, scientists and even for individuals without scientific background... This book is also a good resource for basic understanding of the neurovascular unit that comprises of blood vessels, neighboring astrocytes and adjacent neurons. It succinctly summarizes the bidirectional communication within this unit... This short book is a perfect reference for people who want to understand how brain gets the blood it needs and how it keeps dangerous molecules away from its borders. - Adviye Ergul, Medical College of Georgia This is a great little volume that provides an up to date and concise description of the anatomical and functional bases of the cerebral circulation, from an expert in the field... Dr. Cipolla's book is definitively the place to go for a comprehensive overview of the cerebral circulation and would be a valuable source of information for those interested in cerebrovascular physiology and pathophysiology. The extensive number of recent references provides a useful source for those seeking more information. Definitely a keeper! - Costantino Iadecola, Cornell Medical School In The Cerebral Circulation (second edition), Dr. Marilyn Cipolla presents an update to her successful and well-cited monograph dealing with this fascinating and clinically essential topic. This edition of The Cerebral Circulation will be of interest to both basic and clinical researchers interested in the regulation of cerebral blood flow as well as large and small vessel disease and their implications for brain health and disease. The presentation is mechanistic and up-to-date. With so many specialized reviews appearing in the literature these days, a summary like this that gives a broad, but still fairly detailed overview of the cerebral circulation can be a valuable resource. - Frank M. Faraci, Ph.D., University of Iowa

""The Cerebral Circulation has been an excellent source of information on the structure and function of blood vessels of the brain for graduate students, medical students, scientists and even for individuals without scientific background... This book is also a good resource for basic understanding of the neurovascular unit that comprises of blood vessels, neighboring astrocytes and adjacent neurons. It succinctly summarizes the bidirectional communication within this unit... This short book is a perfect reference for people who want to understand how brain gets the blood it needs and how it keeps dangerous molecules away from its borders."" - Adviye Ergul, Medical College of Georgia ""This is a great little volume that provides an up to date and concise description of the anatomical and functional bases of the cerebral circulation, from an expert in the field... Dr. Cipolla's book is definitively the place to go for a comprehensive overview of the cerebral circulation and would be a valuable source of information for those interested in cerebrovascular physiology and pathophysiology. The extensive number of recent references provides a useful source for those seeking more information. Definitely a keeper!"" - Costantino Iadecola, Cornell Medical School ""In The Cerebral Circulation (second edition), Dr. Marilyn Cipolla presents an update to her successful and well-cited monograph dealing with this fascinating and clinically essential topic. This edition of The Cerebral Circulation will be of interest to both basic and clinical researchers interested in the regulation of cerebral blood flow as well as large and small vessel disease and their implications for brain health and disease. The presentation is mechanistic and up-to-date. With so many specialized reviews appearing in the literature these days, a summary like this that gives a broad, but still fairly detailed overview of the cerebral circulation can be a valuable resource."" - Frank M. Faraci, Ph.D., University of Iowa

Author Information

Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota LSU Health Sciences, Shreveport

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