Overview

This study describes the physiological mechanisms that influence the passage of compounds across the blood-brain barrier located at the level of cerebral microvessels. It considers how pharmaceutical scientists can predict the brain uptake of drugs with in vitro systems or computation from a series of physiochemical parameters.

Full Product Details

Author:   Michael Bradbury ,  David Begley ,  Jorg Kreuter
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.20cm , Height: 1.80cm , Length: 22.90cm
Weight:   0.476kg
ISBN:  

9780824703943

ISBN 10:   0824703944
Pages:   264
Publication Date:   16 May 2000
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain Michael W. Bradbury Physicochemical Factors that Influence Brain Uptake Michael H. Abraham and James A. Platts The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers Christiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helmut Franke, Matthias Haselbach, Joachim Wegener, and Hans-Joachim Galla In Vitro Models of the Blood-Brain Barrier and Their Use in Drug Development R. Cecchelli, B. Dehouck, L. Descamps, L. Fenart, V. Buée-Scherrer, C. Duhem, G. Torpier, and M. P. Dehouck The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain Barrier A. G. de Boer, Elizabeth C. M. de Lange, Inez C. J. van der Sandt, and Douwe D. Breimer The Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the Brain David J. Begley, Anthony Regina, Françoise Roux, Ehsan Ullah Khan, Christopher Rollinson, and Joan Abbott The Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model System Ulrich Mayer Specific Mechanisms for Transporting Drugs Into Brain Akira Tsuji Drug Metabolism in the Brain: Benefits and Risks Alain Minn, Ramon D. S. El-Bachá, Claire Bayol-Denizot, Philippe Lagrange, Funmilayo G. Suleman, and Daniela Gradinaru Targeting Macromolecules to the Central Nervous System Ulrich Bickel Using Nanoparticles to Target Drugs to the Central Nervous System Jörg Kreuter and Renad N. Alyautdin Basic CNS Drug Transport and Binding Kinetics In Vivo Albert Gjedde, Antony D. Gee, and Donald Frederick Smith

Reviews

.."".a compact monograph that brings readers up to date on the blood-brain barrier and how scientists determine drug/chemical permeability across this functional partition....The contributions are a scholarly insight....provides good current information for scientists exploring the blood-brain barrier or working with chemical transport across its borders. Several exciting areas of research are spotlighted, introducing models to predict drug entry and distribution and using in vitro models of the barrier to predict chemical transport....an invaluable resource. ""- Veterinary Human Toxicology, 2000

.. .a compact monograph that brings readers up to date on the blood-brain barrier and how scientists determine drug/chemical permeability across this functional partition....The contributions are a scholarly insight....provides good current information for scientists exploring the blood-brain barrier or working with chemical transport across its borders. Several exciting areas of research are spotlighted, introducing models to predict drug entry and distribution and using in vitro models of the barrier to predict chemical transport....an invaluable resource. - Veterinary Human Toxicology, 2000

Author Information

David J. Begley, Michael W. Bradbury, Jörg Kreuter

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