Overview

The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman's peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology. Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also: * Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistry * Presents specific applications to supramolecular and stereospecific synthesis * Discusses ke y aspects of peptide and protein chemistry--such as molecular recognition, conformation, and folding--in terms of the amide linkage * Includes chapters contributed by numerous eminent chemists and biochemists Organic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.

Full Product Details

Author:   Arthur Greenberg ,  Curt M. Breneman ,  Joel F. Liebman
Publisher:   John Wiley and Sons Ltd
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 15.50cm , Height: 2.90cm , Length: 24.10cm
Weight:   0.930kg
ISBN:  

9780471420255

ISBN 10:   0471420255
Pages:   672
Publication Date:   11 November 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Out of Stock Indefinitely
Availability:   Awaiting stock  

Table of Contents

Preface.Contributors.The Electron Density Distribution of Amides and Related Compounds (C. Breneman & M. Martinov).Origin of the Amide Rotational Barrier (K. Wiberg).The Amide Linkage as a Ligand--Its Properties and the Role of Distortion (A. Greenberg).Studies in Amide Hydrolysis: The Acid, Base, and Water Reactions (R. Brown).The Thermochemistry of Amides (J. Liebman, et al.).Stereospecificity in the alpha-Lactam (Aziridinone) Synthon (R. Hoffman).beta-Lactams: Cyclic Amides of Distinction (A. Bose, et al.).Sterically Hindered Twisted Amides (S. Yamada).Photoelectron Spectroscopy of Amides and Lactams (P. Rademacher).The Role of Amides in the Noncovalent Synthesis of Supramolecular Structures in Solution, at Interfaces, and in Solids (G. Palmore & J. MacDonald).beta-Lactam Antibacterial Agents: Computational Chemistry Investigations (D. Boyd).Three-Dimensional Design of Enzyme Inhibitors with Heterocyclic Amide Bond Mimics (R. Bohacek & W. Shakespeare).Ab Initio Conformational Analysis of Protein Subunits: A Case Study of the Serine Diamide Model (A. Perczel & I. Csizmadia).Gas-Phase Ion Chemistry of Amides, Peptides, and Proteins (C. Cassady).beta-Sheet Interactions Between Proteins (S. Maitra & J. Nowick).Head-to-Tail Cyclic Peptides and Cyclic Peptide Libraries (A. Spatola & P. Romanovskis).From Crystal Structures of Oligopeptides to Protein Folding: The Importance of Peptide Bond-Side Chain Hyperconjugation (A. Cieplak).Role of the Peptide Bond in Protein Structure and Folding (N. Kallenbach, et al.).Index.

Reviews

Author Information

ARTHUR GREENBERG, PhD, is Professor in the Department of Chemistry at the University of New Hampshire. CURT M. BRENEMAN, PhD, is Professor in the Department of Chemistry at Rensselaer Polytechnic Institute. JOEL F. LIEBMAN, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland, Baltimore County.

Tab Content 6

Author Website:  

Countries Available

All regions