Overview

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.

Full Product Details

Author:   Clifford Rosen (Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA) ,  Julie Glowacki (Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School and Harvard School of Dental Medicine, Boston, Massachusetts, U.S.A.) ,  John P. Bilezikian (Columbia University, New York, New York, U.S.A.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 3.20cm , Length: 27.90cm
Weight:   1.810kg
ISBN:  

9780120986552

ISBN 10:   0120986558
Pages:   642
Publication Date:   19 August 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

General Aspects and Models of Aging: D. Nelson, Aging Through the Ages. S. Sherman, Aging in the Human Species. R.P. Heaney, Aging and Calcium Balance. D.N. Kalu, Whole Animal Models of Aging. L. Lipson, Humans. J. Glowacki, Cellular Models. Determinants of Peak Bone Mass; Maintenance of Peak Bone Mass: E. Seeman, Genetics. T. Lloyd, Nutritional. M. van der Meulen and D. Carter, Environmental/Mechanical. M. Warren, Hormonal Influences on the Establishment of Peak Bone Mass. N.H. Bell, Racial. D.T. Baran, Determinants of Maintenance of Bone Mass. Mechanisms of Age-Related Bone Loss: P. Robey, Cellular. M. Leboff and J. Glowacki, Sex Steroids. S.J. Silverberg and J.P. Bilezikian, Parathyroid Hormone. F.M. Gloth, Vitamin D. M. Horowitz and L. Raisz, Cytokines. S. Mohan, Growth Hormone/IGFs. P.H. Stern and P. Lakatos, Other Factors. J. Anderson, Nutritional. C.T. Rubin and J. Rubin, Constraints of Experimental Paradigms Used to Model the Aging Skeleton. Quantifiable Manifestations of Age-Related Bone Loss: M.L. Villa and D. Nelson, Racial/Ethnic Influences on Bone Loss. J. Compston, Histomorphometric. C. Mautalen, Densitometric. C. Gundberg, S. Robins and M. Seibel, Biochemical Dynamics. D. Burr and C.H. Turner, Biomechanical Measurements. Fractures: A Consequence of the Aging Skeleton: M.L. Bouxsein, Applications of Biomechanics to the Aging Human Skeleton. R.D. Wasnich, What is a Fragility Fracture? P.D. Ross, Epidemiology/Economics of Osteoporotic Fractures. M. Nevitt, Sites of Fracture-Spine, Hip, Colles, Other. M. August, L. Kaban, The Aging Maxillo-Facial Skeleton. D. Gold, Effects on the Quality of Life. T. Einhorn and Moffett, General Orthopedics Principles. R. Rizzoli, Nutritional and Supportive. P. Leong, Analgesic Management. Therapeutics: T. Thornhill and M. Winemaker, Complications of Prosthetic Replacements. M. Sinaki, The Shape and Size of an Osteoporotic Woman. D.P. Kiel, Prevention of Falls. R. Marcus and B. Beck, Physical Activity. R.L. Prince, Calcium. R. Lindsay and F. Cosman, Estrogen. E.S. Siris and D. Schussheim, SERMS. E.S. Orwoll, Androgens. S. Papapoulos, Biphosphonates. C. Waud and J. Stock, Calcitonin. A.B. Hodsman, Parathyroid Hormone. C.J. Rosen, Growth Hormone-IGF-1. D. Baylink, Fluoride. M. Favus, Vitamin D.

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Author Information

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor. Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals. Dr. Bilezikian, Professor of Medicine and Pharmacology at the College of Physicians and Surgeons, Columbia University is the Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia-Presbyterian Medical Center. He also serves as Associate Chair, Department of Medicine. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians and Surgeons. He completed four years of house staff training (internship and residency) including the Chief Medical Residency of the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH where he served as a Clinical Associate in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies, including the American Society for Bone and Mineral Research, of which he served as President in 1996. He is a member of the Endocrine Society, the American Federation for Clinical Research, the American Society for Clinical Investigation, the Association of American Physicians, the American Association of Clinical Endocrinologists, the American Society for Pharmacology and Experimental Therapeutics, and the International Society of Clinical Densitometry, of which he is President. He is Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism. His books include Editor-in-Chief of The Parathyroids (1994), and co-editor of Principles of Bone Biology (1996), The Aging Skeleton (1999), and Dynamics of Bone and Cartilage Metabolism (1999). He has been on numerous panels, including serving as Chair of the NIH Consensus Development Panel on Optimal Calcium Intake, and the Food and Nutrition Board of the National Academy of Sciences. He is a major national and international spokesperson for the field of metabolic bone diseases. Dr. Bilezikian's major research inte

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