Overview

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties

Full Product Details

Author:   Alan Talevi
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2022
Weight:   2.723kg
ISBN:  

9783030848590

ISBN 10:   3030848590
Pages:   1200
Publication Date:   20 May 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Drug dissolution and drug release Mathematical models of drug dissolution and drug release Diffusion layer model Danckwert’s model Interfacial barrier model First order model Higuchi model Korsmeyer-Peppas model Hixson-Crowell model Baker-Lonsdale model Weibull model In vitro dissolution testing Modalities of dissolution tests Biorelevant dissolution media   Drug absorption Free diffusion Facilitated diffusion Active transport Transcytosis pH partition theory pKa determination Factors impacting drug absorption   Drug distribution Factors impacting drug distribution Real volume of distribution Apparent volume of distribution Drug binding to plasma proteins Drug displacement Non-linear binding to plasma proteins Drug binding to tissue components One-compartment pharmacokinetic model Two-compartment pharmacokinetic model Central nervous system bioavailability Blood-brain barrier log BB Kpuu   Drug metabolism Functionalization reactions Synthetic reactions Cytochrome P450 Phase III reactions Factors impacting on drug metabolism Genetic variants. Polymorphism Age Gender Environmental factors: enzyme induction Precision medicine Pharmacogenomic DNA chips Microsomes    Drug excretion Biliary excretion Enterohepatic recycling Enterohepatic recycling and antibiotics Renal excretion Glomerular filtration Tubular reabsorption Tubular secretion Clearance Organ clearance   Routes of administration Oral route Migrating motor complex Enteric coating tablets Food-drug interactions Gastric emptying Gastroretentive drug delivery systems Multiparticulate drug delivery systems Gut microbiota Lipinski rule of five Permeation enhancers Intestinal perfusion models Bucal and sublingual route Rectal route Intravenous route Intravenous bolus Intravenous infusion Technological considerations for intravenous administration Intramuscular administration Subcutaneous administration Specialized parenteral routes Pulmonary administration Nasal administration Transdermal administration Permeation enhancers   Next generation drug delivery systems Nanocarriers Surface-to-volume ratio Surface chemistry Nanotoxicology Drug release from nanocarriers Passive targeting Smart systems / stimuli-responsive systems Active targeting Mononuclear phagocyte system Absorption and distribution of nanocarriers Elimination of nanocarriers PEGylationADME Viral vectors   Pharmacogenomics Enzyme polymorphism Transporter polymorphism Pharmacogenomics and pediatrics   Bioavailability and bioequivalence Bioavailability Systemic bioavailability Generic drugs Post-approval changes Bioequivalence Absolute bioavailability Mass balance studies Bioequivalence studies Reference and test products Biopharmaceutical Classification System Biowaivers BCS subclasses Dissolution testing Pharmacodynamic studies   Biopharmaceutical drug products Absorption of protein drugs Distribution of protein drugs Elimination of protein drugs ADME properties of insulins ADME properties of heparins ADME properties of gene-based biopharmaceuticals   Drug-drug and food-drug interactions Plasma protein binding DDI Membrane transport DDI Metabolism DDI FDI based on induction of gastrointestinal changes   In vitro and in silico ADME predictions Polarized cell lines Caco-2 MDCK Solubility Dissolution testing QSPR/QSAR Expert rules Central Nervous System Multiparameter Optimization Dynamic transit models Sandwich-cultured hepatocytes Single-cell expression systems Membrane vesicles Molecular dynamics simulations   Drug tansporters ABC transporters MDR1 MRPs BCRP Solute carriers Organic anion transporters Organic cation transporters Peptide transporters   Non-linear pharmacokinetics Linear pharmacokinetics Positive deviations from linear behavior Negative deviations from linear behavior   Time-dependent pharmacokinetics   Pharmacometrics and physiologic models    

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Author Information

Prof. Alan Talevi was born in Buenos Aires, 1980. He obtained his Pharmacy degree in 2004 and completed his PhD studies in 2007, both at the University of La Plata (UNLP, Argentina). Among other recognitions, he obtained the award for the best PhD thesis on Computational Chemistry from the Argentinean Chemical Society (2008), a Pacifichem Young Scholar Award (USA, 2010) and the Award to Scientific and Technological Production at UNLP (2016). Since 2010, he holds a permanent position at the Argentinean Council of Scientific and Technical Research (CONICET), where he currently occupies an Independent Researcher position, and since 2012 he is the professor in charge of the Biopharmacy/Pharmacokinetics course at the Faculty of Exact Sciences, UNLP. He has published over 80 articles in periodicals and more than 30 book chapters, mostly in the fields of machine learning, drug discovery and biopharmacy. He was elected Head of the Department of Biological Sciences of the Faculty of Exact Sciences, UNLP, between 2015 and 2017. In 2018 he became the Head of the Laboratory of Bioactive Research and Development (LIDeB, UNLP). External reviewer for several agencies and universities, including the Argentinean National Institute of Cancer, Argentinean National Agency of Scientific and Technical Promotion, Argentinean Ministry of Education, University of La República (Uruguay), University of Buenos Aires (Argentina), University of Córdoba (Argentina), University of Mar del Plata (Argentina), the National Agency of Scientific and Technical Promotion (Uruguay), the United Nations University, the National Science Center (Poland) and the “Victor Babes” University of Medicine an Pharmacy (Romania), CONCYTEC (Perú), and UK Research and Innovation (UK). Reviewer of more than 80 periodicals (https://publons.com/researcher/1667052/alan-talevi/), mostly in the fields of Cheminformatics, Drug Discovery, Drug Design and Pharmacology, including the Nature Communications, Scientific Reports, Journal of Medicinal Chemistry, Journal of Chemical Information and Modelling, Journal of Molecular Graphics and Modelling, Expert Opinion on Drug Delivery, Expert Opinion on Drug Discovery, Expert Opinion on Drug Metabolism and Toxicology, European Journal of Medicinal Chemistry, European Journal of Pharmacology, International Journal of Pharmaceutics, Journal of Pharmacy and Pharmacology. Member of the editorial board of the Latin American Journal of Pharmacy (from 2014 and continues). Guest editor of Mini-Reviews in Medicinal Chemistry, Frontiers in Chemistry and Current Drug Safety. Editor of the Antiepileptic Drug Discovery Novel Approaches volume of the Springer Protocols series (2016), and also of ADME Processes in Pharmaceutical Sciences Dosage, Design, and Pharmacotherapy Success (Springer, 2018). Editor of the imminent Springer Nature Computer-Aided Drug Discovery and Design series (ongoing). Editor of the book Biopharmaceutical processes (UNLP Publishing - EdULP, 2016). He has taught several courses in Argentina, Uruguay and Mexico. He has been recipient of several national and international research grants.

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