Overview

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

Full Product Details

Author:   Nigel M Hooper ,  Uwe Lendeckel
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2005 ed.
Volume:   4
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.705kg
ISBN:  

9780387251493

ISBN 10:   0387251499
Pages:   344
Publication Date:   23 June 2005
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Contributing Authors; Preface; Chapter 1: INTRODUCTION TO THE ADAM FAMILY, Judith White, Lance Bridges, Douglas DeSimone, Monika Tomczuk and Tyra Wolfsberg; Chapter 2: STUDIES FROM ADAM KNOCKOUT MICE, Keisuke Hoiruchi and Carl P. Blobel; Chapter 3: ADAM8/MS2/CD156a, Jörg W. Bartsch, Silvia Naus, Andrea Rittger, Uwe Schlomann, Dirk Wildeboer; Chapter 4: ADAM9, Shoichi Ishiura; Chapter 5: ADAM10, Paul Saftig and Dieter Hartmann; Chapter 6: ADAM12, Ulla M. Wewer, Reidar Albrechtsen and Eva Engvall; Chapter 7: Adam13 function in development, Dominique Alfandari, Chapter 8: ADAM 17, Joaquín Arribas and Soraya Ruiz-Paz; Chapter 9: ADAM19, Tiebang Kang, Robert G. Newcomer, Yun-Ge Zhao and Qing-Xiang Amy Sang;Chapter 10: ADAM28, Anne M. Fourie; Chapter 11: MAMMALIAN ADAMS WITH TESTIS-SPECIFIC OR -PREDOMINANT EXPRESSION, Chunghee Cho; Chapter 12: OVERVIEW OF ADAMTS PROTEINASES AND ADAMTS 2, Daniel S. Greenspan and Wei-Man Wang;Chapter 13: ADAMTS-3 AND ADAMTS-14, Carine Le Goff and Suneel S. Apte; Chapter 14: ADAMTS-4 AND ADAMTS-5, Anne-Marie Malfait, Micky Tortorella and Elizabeth Arner; Chapter 15: ADAMTS-13, Han-Mou Tsai; Index.

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