The Actin Cytoskeleton and Bacterial Infection
Author:   Hans Georg Mannherz
Publisher:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Volume:   399
ISBN:  

9783319843056


Pages:   242
Publication Date:   13 July 2018
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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The Actin Cytoskeleton and Bacterial Infection


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Overview

This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton. In short, this volume provides an overview of the various tricks bacteria have evolved to “act on actin” in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.

Full Product Details

Author:   Hans Georg Mannherz
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Volume:   399
Weight:   0.454kg
ISBN:  

9783319843056


ISBN 10:   3319843052
Pages:   242
Publication Date:   13 July 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Actin structure and dynamics.- Influence of binary actin-depolymerizing toxins on the microtubule system.- ADP-ribosylation of actin by Photorhabdus luminescens TccC3 inhibits interaction with actin binding proteins essential for treadmilling.- Pathogenic mechanisms of actin cross-linking toxins – peeling away the layers.- New concepts on bacterial effectors targeting Rho GTPases.- Interaction of bacterial ADPribosyltransferases with actin.- Yersinia's ways to activate and inactivate actin rearrangements in host cells.- The role of formins in phagocytosis of Borrelia by macrophages.

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Author Information

Hans Georg MannherzRuhr-Universität BochumInstitut für AnatomieAbteilung für Anatomie und molekulare Embryologiee-mail: Hans.Mannherz@ruhr-uni-bochum.de

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