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OverviewThe Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Full Product DetailsAuthor: Ajay K. Singh (Clinical Chief, Renal Division, Brigham and Women's Hospital; Associate Professor of Medicine, Harvard Medical School, Cambridge, MA, USA) , Gordon H. Williams (Director, Center for Clinical Investigation, Brigham and Women's Hospital, Professor of Medicine, Harvard Medical School, Cambridge, MA, USA) , Gordon H. Williams (Director, Center for Clinical Investigation, Brigham and Women's Hospital, Professor of Medicine, Harvard Medical School, Cambridge, MA, USA)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Dimensions: Width: 21.60cm , Height: 3.60cm , Length: 27.60cm Weight: 1.690kg ISBN: 9780123738707ISBN 10: 0123738709 Pages: 522 Publication Date: 23 December 2008 Audience: College/higher education , Undergraduate Replaced By: 9780128032473 Format: Hardback Publisher's Status: Active Availability: In Print ![]() This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsPart 1: The Kidney as an Endocrine Organ Section 1: Erythropoietin 1. Erythropoientin: An Historical Overview of Physiology, Molecular Biology And Gene Regulation 2.Erythropoiesis: The Role of Erythropoietin and Iron 3.Extra-Hematopoietic Action of Erythropoietin 4.Development of Recombinant Erythropoietin and Erythropoietin Analogues 5.Erythropoietin Disease States & Resistance Section 2: Vitamin D, PTH and Novel Regulators of Phosphate 6. Vitamin D and the Kidney: Introduction and Historical Perspective 7.Vitamin D: Molecular Biology and Gene Regulation 8.Molecular Biology of Parathyroid Hormone 9.Endocrine Regulation of Phosphate Homeostasis Section 3: Renin-angiotensin 10.Introduction and Historical Overview 11.Molecular Biology of Renin and Regulation of Its Gene 12. Physiology and Regulation of the RAAS System 13. The Renin Angiotensin Aldosterone System and the Kidney 14. The Renin Angiotensin and the Heart 15. The Renin-Angrotensin blockade: Therapeutic Agents Part 2: The Kidney as a Hormonal target Section 4: Anti-diuretic Hormone 16. Vasopressin in the Kidney: Historical Aspects 17. Molecular Biology and Gene Regulation 18. Vasopressin Antagonists in Physiology and Disease 19. Diabetes Insipidus and SIADH Section 5: The Atrial Natriuretic Peptides 20. ANP, BNP and CNP Physiology and Pharmacology of the Cardiorenal Axis Section 6: Aldosterone 21.Introduction and Historical Overview 22.Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation 23. Aldosterone and Its Cardiovascular Effects 24. Aldosterone Regulation Section 7: Endocrine Disorders in Renal Failure 25. Insulin resistance 26. Growth hormone 27. Sexual Dysfunction in Men and Women with Chronic Kidney Disease 28. Thyroid Status in Chronic Renal Failure Patients 29.Metabolic Acidosis of Chronic Kidney Disease 30.Pregnancy and the KidneyReviewsSingh and Williams have clearly chosen their authors well. The experts responsible for each chapter are clearly very knowledgeable and did an outstanding job of sharing that knowledge with the reader. Very often in books of this kind the density of the detail makes the reading rather difficult. Not in the case of this monograph. The reading is easy ---Norman K. Hollenberg, M.D., Ph.D., Department of Medicine, Brigham and Women's Hospital, Harvard, Boston, MA, USA This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis - an unusual event in this era of online material. -- As reviewed in N Engl J Med 2009; 361: 832 All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading. -- Kidney International (2009) This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis - an unusual event in this era of online material. -- As reviewed in N Engl J Med 2009; 361: 832 All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading. -- Kidney International (2009) This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis - an unusual event in this era of online material. -- As reviewed in N Engl J Med 2009; 361: 832 All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading. -- Kidney International (2009) Written by multidisciplinary experts from several countries, this book is divided into 2 parts and 7 sections. A very useful volume. Each chapter is richly referenced. -- Zvi Laron, Pediatric Endocrinology Reviews Author InformationDr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University. Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology. Tab Content 6Author Website:Countries AvailableAll regions |