Overview

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Full Product Details

Author:   Tommy Liljefors (Royal Danish School of Pharmacy, Copenhagen, Denmark) ,  Povl Krogsgaard-Larsen (The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark) ,  Ulf Madsen (University of Copenhagen, Denmark)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   3rd New edition
Dimensions:   Width: 17.80cm , Height: 4.40cm , Length: 25.40cm
Weight:   1.429kg
ISBN:  

9780415282888

ISBN 10:   0415282888
Pages:   592
Publication Date:   25 July 2002
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

DRUG DESIGN AND DISCOVERY: AN OVERVIEW Lester A. Mitscher Introduction Historical Perspective What Kinds of Compounds Become Drugs? Preparation and Organization for Drug Seeking Sources of Hits, Leads, and Candidate Drugs Lead Optimization Cell Biology and Genomics as a source of Drug Targets Future Developments ROLE OF MOLECULAR RECOGNITION IN DRUG DESIGN Peter Andrews and Michael Dooley Introduction Thermodynamic Considerations of Drug Binding The Physical Basis of Intermolecular interaction The Total Energy of Intermolecular interaction Estimating Individual Group Components in Ligand-Receptor Interactions and Co- Operativity Some Rules of Thumb STEREOCHEMISTRY IN DRUG DESIGN Ian J. Kennedy and David E. Jane Introduction What Are Stereoisomers? The Origin of Stereospecificity in Molecular Recognition Why is Stereochemistry Important in Drug Design? Methods of Obtaining Pure Stereoisomers Analytical Methods of Determining Purity of Stereoisomers COMPUTER-AIDED DEVELOPMENT OF THREE-DIMENSIONAL PHARMACOPHORE MODELS Tommy Liljefors and Ingrid Petterson Structure-and Pharmacophore-Based Ligand Design The Pharmacophore Concept Basic Principles and a Step-By-Step Procedure Pharmacophore Elements and Their Representations The Receptor-Bound or 'Active' Conformation Molecular Superimposition Receptor-Excluded and Receptor-Essential Volumes Solvation Effects Examples of 3D-Pharmacophore Models and Their Use QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS AND EXPERIMENTAL DESIGN Ulf Norinder and Thomas Hoberg Introduction Hansch Analysis Physico-Chemical Properties Applications of Hansch Equations Pattern Recognition 3D-QSAR Methodologies Experimental Design RECEPTORS: STRUCTURE, FUNCTION AND PHARMACOLOGY Hans Brauner-Osborne Introduction Receptor Structure and Function Receptor Pharmacology

Reviews

Describing all facets of modern drug design and development, this major textbook is an invaluable source of information for students of chemistry, phamacology, pharmacy, medicinal chemistry, medicine and biochemistry at all levelsAlmost every page is illustrated with figures, tables and structural formulae. Unlisted Drugs A well-structured and informative book S. Damment, Glaxo, Newsletter of British Society for Toxicology Excellent bookThe editors set a high standard. Professor Graham Johnston, TiPS a good and substantial bookgood introductions to many aspects of a complex subject Chris Ramsden, Chemistry and Industry

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