Overview

This comprehensive textbook brings together global experts to deliver an in depth, evidence based guide covering the full spectrum of acquired and inherited marrow failure syndromes. It explores cutting edge advances in diagnostics including next generation sequencing , other genetic studies and the evolving progress in  treatment strategies including  immunosuppressive therapy, hematopoietic stem cell transplantation, and targeted agents. Special attention is given to age specific management, overlap syndromes and the increasingly recognized inherited bone marrow failure disorders. A dedicated section addresses the unique challenges faced in resource limited settings, offering strategies to improve global access to care. Designed for clinicians, researchers, and allied health professionals, this textbook serves as an essential, practical reference that bridges research and real world practice. It equips readers with the tools to improve outcomes for patients worldwide affected by bone marrow failure.  This book is open access.

Full Product Details

Author:   Mahmoud Aljurf ,  Régis Peffault de Latour ,  Antonio M. Risitano ,  Andrea Bacigalupo
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
ISBN:  

9783032023858

ISBN 10:   3032023858
Pages:   381
Publication Date:   26 March 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

Epidemiology of Acquired Bone Marrow Failure.- Pathophysiology of Acquired Bone Marrow Failure.- Role of Next Generation Sequencing in Diagnosis of Inherited and Acquired Bone Marrow Failure.- Diagnosis of Acquired Aplastic Anemia.- Acquired Overlap Bone Marrow Failure Disorders.- Supportive Care in Aplastic Anemia.- Immunosuppressive Therapy for Aplastic Anemia.- Identical Sibling Donor Transplantation.- Unrelated Donor Transplants for Acquired Aplastic Anemia.- Umbilical Cord Blood Transplantation for Patients.- Haploidentical Transplantation.- Management of Acquired Aplastic Anemia in Children.- Treatment of Elderly Patients with Aplastic Anemia.- Emerging New Therapies for Acquired Bone Marrow Failure Disorders.- Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria.- Managing Bone Marrow Failure in Countries with Restricted Resource.- Telomere Biology and Disease.- Fanconi Anemia.- Ribosomopathies and the Quality Control of Ribosome Assembly.- Dyskeratosis Congenita.- Amegakaryocytic Thrombocytopenia.- Severe Congenital Neutropenias and Other Rare Inherited Disorders with Marrow Failure.- Bone Marrow Failure Syndromes in Children.

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Author Information

Dr. Mahmoud Aljurf MD Director of Adult Stem Cell Transplantation and Cell Therapy Program Deputy Director of the Oncology Centre King Faisal Specialist Hospital & Research Centre Riyadh, Saudi Arabia   Régis Peffault de Latour Professor of Hematology Department of Hematology and Bone Marrow Transplant Saint-Louis Hospital Paris, France   Antonio M Risitano Head of the Clinical Unit of Hematopoietic Stem Cell Transplantation Department of Hematology Moscati Hospital Avellino, Italy     Andrea Bacigalupo Fondazione Policlinico Universitario Gem Rome, Italy   Carlo Dufour Chair of the Clinical and Experimental Hematology Unit Department of Hematology G. Gaslini Children Research Hospital Genova, Italy

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