Overview

This book contains the first collection of selected tests for the evaluation of blood compatible materials. The tests are given as recipes, including a list of equipment and materials used in each particular test, which means that persons not very well versed in the field are able to perform the tests. In most tests reference results are given to provide further guidance. Researchers from many countries have contributed. The text includes the following: guidelines for Selecting Animals, Testing for Mechanical Properties, Biodegradation, Surface Analysis, Detection of Protein Adsorption, Activation of Haemostasis and other Activation Systems, Detection of Thrombosis, Fibrinolysis and Emboli formation and Detection of Toxicity. A separate chapter on rules for good manufacturing Practice and Good Laboratory Practice is included. This book is of great value for range of disciplines, from the experimental research laboratory to the official approval laboratory.

Full Product Details

Author:   S. Dawids
Publisher:   Springer
Imprint:   Springer
Edition:   1993 ed.
Dimensions:   Width: 15.50cm , Height: 3.80cm , Length: 23.50cm
Weight:   2.550kg
ISBN:  

9780792321071

ISBN 10:   0792321073
Pages:   684
Publication Date:   30 April 1993
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

I General Introduction.- Haemocompatibility: What does it mean?.- Guidelines for selecting the proper animal species for a particular test.- II Test Methods for the Detection of Mechanical Properties.- Test for short time stress and strain.- Test for tensile stress.- Test for tear strength.- Test for dynamic stress and strain.- Test for material fatigue.- Test for creep, relaxation and set.- Test for material compliance.- Test for porosity of vascular grafts.- III Test Methods for the Detection of Biodegradation.- Boiling test for in vitro degradation of biomaterials.- Enzymatic in vitro degradation of polymers.- Tissue implantation test.- IV Test Methods for Surface Analysis.- Electron spectroscopy for chemical analysis (ESCA).- Secondary ion mass spectroscopy (SIMS).- Fourier transform attenuated total reflection infrared spectroscopy (ATR/FT-IR).- Fourier transform attenuated total reflection infrared spectroscopy (ATR/FT-IR): Application to proteins adsorption studies.- Calcium-thiocyanate method for the quantification of sites on polymer surfaces.- Contact angles and surface free energies of solids.- Scanning electron microscopy (SEM).- V Test Methods for the Detection of Protein Adsorption on Polymers.- Test for plasma protein adsorption to biomaterials using an enzyme-immunoassay.- The detection of adsorbed plasma proteins from membrane materials using SDS-polyacrylamide gel electrophoresis of desorbed proteins.- Reflectrometry as a tool for dynamically measuring protein adsorption.- Measurement of protein adsorption to solid surfaces in relation to blood compatibility using radioiodine labelling methods.- VI Test Methods for the Activation of Haemostasis and other Activation Systems.- Modified resonance thrombography.- Quantitative platelet aggregation in vitro.- Platelet deposition on biomaterials measured with a capillary perfusion model.- Enzyme immunoassay determination of specific proteins in plasma.- Human adult endothelial cell culture conditions for optimal colonization of biomaterials used in vascular surgery.- Determination of protein C in plasma.- A centrifugation technique for the preparation of suspensions of non activated washed human platelets.- Measurement of circulating fibrinopeptide A in plasma.- Assessment of the fibrinolytic system.- VII Test Methods for the Detection of Thrombosis, Fibrinolysis and Emboli Formation.- Dynamic ex vivo thrombogenicity test in modified Dudley test.- Ex vivo acute arteriovenous shunt.- Chronic artificial external arteriovenous shunt.- Intravascular implantation test.- VIII Test Methods for the Detection of Toxicity.- In vitro toxicity test for biomaterials.- In vitro toxicity tests using biological methods.- In vitro cytocompatibility tests.- IX GLP-GMP Rules for Testing of Polymers.- Rules for good laboratory practice (GLP). General considerations.- Rules for good manufacturing practice (GMP). General considerations.- Authors Index.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions