This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
Full Product DetailsAuthor: Neal Lue , Chantal Autexier
Publisher: John Wiley and Sons Ltd
Imprint: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
Dimensions: Width: 16.30cm , Height: 2.20cm , Length: 23.60cm
ISBN 10: 0470592044
Publication Date: 27 July 2012
Audience: Professional and scholarly , Professional & Vocational
Publisher's Status: Active
Availability: In Print
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Table of Contents
<p>NEAL F. LUE, MD, PhD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems.<p>CHANTAL AUTEXIER, PhD, is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms.
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