Overview

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

Full Product Details

Author:   Alfredo Ulloa-Aguirre ,  Ya-Xiong Tao
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   Softcover reprint of the original 1st ed. 2018
Volume:   245
Weight:   0.664kg
ISBN:  

9783030089276

ISBN 10:   3030089274
Pages:   425
Publication Date:   15 February 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Intracellular trafficking of gonadotropin receptors in health and disease.- 2. Investigating internalization and intracellular trafficking of GPCRs.- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors.- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases.- 5. Pharmacoperones for misfolded gonadotropin receptors.- 6. Pharmacological chaperones: Beyond conformational disorders.- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer.- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches.- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking.- 10. SLC6 transporter folding diseases and pharmacochaperoning.- 11. The molecular physiopathogenesis of islet amyloidosis.- 12. Folding defects leading to primary hyperoxaluria.- 13. Potentialpharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.    

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