Overview

This two-volume set provides essential information on the general principles of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modification and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharmacologists, biochemists, and environmental toxicologists.

Full Product Details

Author:   Gerald M. Cohen
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Weight:   1.882kg
ISBN:  

9780849357695

ISBN 10:   0849357691
Pages:   488
Publication Date:   01 January 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

VOLUME I: Basic Principles of Target Organ Toxicity. Role of Pharmacokinetics in Rationalizing Tissue Distortion. Role of Metabolic Activation in Target Organ Toxicity. Role of Excretion. Species Variation in Target Organ Toxicity. Importance of Tissue-Specific Biochemistry in Determination of Target Organ Toxicity. Role of Key Defense Systems in Target Organ Toxicity. Liver as a Organ for Toxicity. Index. 240 pp., 7x10, 1986. VOLUME II: Kidney as a Target Organ for Toxicity. Cardiac Toxicity. Lung as a Target Organ for Toxicity. Target Organ Toxicity: Male Reproductive System. Toxic Effects of the Female Reproductive System. Eye. Inner Ear. Endocrine Pancreas as a Target Organ for Toxicity. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction. Organ Specificity in Tumor Initiation and Complete Carcinogenesis (including Species Variation). Index.

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