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Author:   Jurgen Moll ,  Riccardo Colombo
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 2013
Volume:   986
Dimensions:   Width: 17.80cm , Height: 2.00cm , Length: 25.40cm
Weight:   7.264kg
ISBN:  

9781493962785

ISBN 10:   1493962787
Pages:   371
Publication Date:   19 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

The Path to Oncology Drug Target Validation – an Industry Perspective.- Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity.- The Design and Structure-functional Properties  of DNA-based Immunomodulatory Sequences.- siRNA Design Principles and Off-target Effects.- Western Blot Evaluation of siRNA Delivery by pH Responsive Peptides.- High Throughput RNAi Screening for the Identification of Novel Targets.- Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development.- CellProfiler and KNIME: Open Source Tools for High Content Screening.- PARP Inhibition as a Prototype for Synthetic Lethal Screens.- Structure-Based Target Druggability Assessment.- Validating Pharmacological Disruption of Protein-protein Interactions by Acceptor Photobleaching FRET Imaging.- Systematic Analysis of Complex Signal Transduction Pathways using Protein Fragment Complementation Assays.- Reverse-Phase Protein Microarrays and Their Utility in Drug Development.- A Cell Culture System that Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization.- 2-Dimensional vs. 3-Dimensional in vitro Tumor Migration and Invasion Assays.- Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents.- The NeuroSphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs).-Genetically Engineered Animal Models for in vivo Target Identification and Validation in Oncology.- Target Validation in Mice by Constitutive andConditional RNAi.- In vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models.- Brightfield In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples.- Combined microRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers.

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