Overview

The molecular engineering design and application of polymeric materials for use in delivery systems has evolved into one of the most promising advanced technology areas of polymer science as well as contemporary medical, pharmaceutical, and agricultural science. This volume opens with two chapters providing a perspective on current topics in the field. The remaining twenty-two chapters discuss new and innovative research in the area. They emphasize the role of molecular architecture and associated design and synthesis of new chain molecules and also cover assembling strategies for modulation of release profiles. The authors provide concise accounts of key administration routes and clinical applications. Topics include nanosphere micelles, microspheres, solid implants and injectable liquid gel-formers.

Full Product Details

Author:   Iain McCulloch (Hoechst-Celanese Corporation) ,  Shalaby W. Shalaby (Poly-Med Inc.)
Publisher:   American Chemical Society
Imprint:   American Chemical Society
Volume:   709
Dimensions:   Width: 15.80cm , Height: 2.00cm , Length: 23.60cm
Weight:   0.615kg
ISBN:  

9780841235854

ISBN 10:   0841235856
Pages:   336
Publication Date:   01 July 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   No Longer Our Product
Availability:   In Print  
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Table of Contents

"CRITICAL REVIEWS ; 1. Intravitreal treatment of cytomegalovirus retinitis and the need for controlled release systems ; 2. Key features and future perspectives in the development of intravaginal drug delivery systems ; MOLECULAR DESIGN OF POLYMERIC CARRIERS ; 3. Cationic hydrogels for controlled release of proteins and other macromolecules ; 4. Water soluble polyanions as oral drug carriers: poly(sulfopropyl methacrylate potassium-co-alkyl methacrylate) ; 5. Polymer prodrugs with pharmaceutically active degradation products ; 6. Synthesis of thioester end-functionalized poly-(e-caprolactone) and its application in chemselective ligation ; 7. The ""reactive polymer micelle"", convenient tool for targeting drug delivery system ; 8. Hyperbranched polymeric micelles: drug encapsulation, release, and polymer degradation ; 9. Injectable absorbable gel-formers for the controlled release of bioactive agents/drugs ; 10. Novel ionogenic acrylate copolymer networks for sustained solute delivery ; 11. Direct synthesis of polyester microspheres, potential carriers of bioactive compounds ; STRATEGIES TO MODULATING AND MONITORING THE RELEASE PROFILE ; 12. Novel bioadhesive complexation networks for oral protein drug delivery ; 13. Shell Corss-linked knedels: amphiphilic core-shell nanospheres with unique potential for controlled release application ; 14. Multilayered semicrystalline polymeric controlled release systems ; 15. Electroconductive gels for controlled electrorelease of bioactive peptides ; 16. A new approach to in-situ thermal gelation of alginate for controlled release ; 17. Effect of surfactants on the release of grisefulvin from polyvinylpyrrolidone dispersions ; 18. Self diffusion of solvents and solute probes in polymer solutions and gels as studied by pulsed-gradient NMR spectroscopy: the use of a new physical model of diffusion ; 19. Biodegradation of poly(lacic-co-glycolic acid) oligomers ; 20. Poly(lactic-co-glycolic acid) oligomeric micro0granules for asprin delivery and stabilization ; 21. Antitumor drug delivery by dextran derivatives immobilizing platinum complex (II) through coordination bond ; 22. Potential role of controlled drug delivery in tissue engineering ; 23. Direct measurement of mulitphase flow using controlled release of polymers soluble in single phase ; 24. Structural characterization and effects of gibberellic acid-containing organotin polymers on sawgrass and cattail germination and seedling growth for everglades restoration"

Reviews

<br> This book may be more interesting than most multi-authored works in controlled release because it is the polymer and its behavior that is the central focus of each chapter. In fact, most of the research papers present a new, or nearly new, polymer often including both synthesis and performance results. -- Lisa Brannon-Peppas, Polymer News, Vol 25, No 10<br>

<br> This book may be more interesting than most multi-authored works in controlled release because it is the polymer and its behavior that is the central focus of each chapter. In fact, most of the research papers present a new, or nearly new, polymer often including both synthesis and performance results. -- Lisa Brannon-Peppas, Polymer News, Vol 25, No 10<p><br>

This book may be more interesting than most multi-authored works in controlled release because it is the polymer and its behavior that is the central focus of each chapter. In fact, most of the research papers present a new, or nearly new, polymer often including both synthesis and performance results. -- Lisa Brannon-Peppas, Polymer News, Vol 25, No 10<br>

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