Overview

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

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9780123749949

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Published Review of Fourth Edition<br> The editor's purpose is to provide the reader with the latest information about SLE, its science, presentation, and treatment.This edition of Systemic Lupus Erythematosus continues to be an up-to-date, comprehensive, and well-referenced resource for both the basic science and clinical medicine aspects of this complex disease. The book takes us on a journey starting with the disease pathogenesis, continuing with animal models of lupus, various autoantibodies and antigens, the clinical approach to diagnosis and the affected organs and tissues, and ending with current therapies. It will be an excellent reference book for students of immunology/rheumatology and for experienced research scientists and clinicians. Reflecting the emerging information in this dynamic field, the volume includes new chapters on fibromyalgia and osteoporosis in association with SLE, and enhanced chapters on the molecular aspects of the cellular immunology of SLE, the neurops

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Dr. Lahita is Professor of Medicine at Ruger University, and adjunct Professor at Mount Sinai School of Medicine and the Chairman of Medicine and Vice President of the Ne ark Beth Israel Medical Center. He is a fellow of the ACP, a master of the ACR. Dr. Lahita is author of more than 16 books and 150 scientific publications in the field of autoimmunity. He is the editor of the standard textbook call Systemic Lupus Erythematosus and the Senior Editor of the Textbook of Autoimmunity, published in 2002

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