Overview

Ramya Rajan is a renowned researcher in the field of medicinal chemistry, with a specialization in the synthesis, characterization, and evaluation of hydrazone derivatives. Her work involves both in vitro and in silico studies to investigate the pharmacological potential of these compounds for the treatment of various diseases. Hydrazone derivatives have gained considerable attention in recent years due to their diverse biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Ramya Rajan's research focuses on the design and synthesis of novel hydrazone derivatives and their characterization using advanced techniques such as NMR spectroscopy, FTIR spectroscopy, mass spectrometry, HPLC, TLC, and UV-Vis spectroscopy. Ramya Rajan's work also involves in vitro studies to evaluate the cytotoxicity, apoptosis, and cell cycle effects of these compounds on various cancer cell lines. Additionally, she explores enzyme inhibition mechanisms of hydrazone derivatives and their hydrogen bonding and electronic properties, lipophilicity, ADME, pharmacokinetics, and pharmacodynamics to understand their potential as drug candidates. In silico studies form an essential part of Ramya Rajan's research, where she employs molecular docking, molecular dynamics, molecular mechanics, density functional theory, and quantum mechanics techniques to elucidate the molecular mechanisms underlying the biological activities of hydrazone derivatives. Her research also involves structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR) studies, molecular recognition, and protein-ligand interactions to optimize lead compounds and rational drug design. The ultimate goal of Ramya Rajan's research is to develop hydrazone derivatives with improved pharmacological properties, bioavailability, and chemical stability. Her work also focuses on assessing the toxicity of these compounds to ensure their safety for use in humans. Her extensive research in the field of medicinal chemistry using in vitro and in silico studies and advanced analytical techniques has significantly contributed to the development of novel hydrazone derivatives for drug discovery and optimization.

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9781805290322

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