Overview

Cleft lip and palate (CLP) are among the most common congenital craniofacial anomalies, often occurring as part of various syndromic conditions. Syndromic CLP is associated with over 300 syndromes, including Van der Woude syndrome, Pierre Robin sequence, Treacher Collins syndrome, and 22q11.2 deletion syndrome. These syndromes frequently involve additional anomalies affecting the airway, hearing, speech, dentition, and facial growth.Early diagnosis is crucial for optimal care. Management requires a multidisciplinary approach, involving oral and maxillofacial surgeons, pediatricians, ENT specialists, speech therapists, orthodontists, and psychologists. Treatment includes staged surgical correction of the cleft, airway and feeding support, speech therapy, and orthodontic intervention, tailored to the specific syndrome.Advancements in genetic diagnostics and individualized treatment protocols have significantly improved outcomes. Understanding the syndromic context is essential for anticipating complications, planning interventions, and providing comprehensive care.

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