Overview

This volume covers some powerful biophysical methods, such as analytical centrifugation, mass spectrometry, fluorescence spectroscopy, electron spin resonance and nuclear magnetic resonance, for the study of complex biological structures, and discusses useful physical concepts as applied to biological and biochemical systems. Case-orientated studies concentrating on particular methodologies are presented and examples are given, addressing some of the most important aspects of structure-function relationship in biological assemblies. Biophysics nowadays collaborates closely with molecular biology and bioinformatics and this is also demonstrated in this book. The book will be of interest both to experienced researchers wishing to widen their insight into molecular structure and function, and to younger scientists at the doctoral and postdoctoral level interested in the molecular nature of fundamental biological entities and phenomena.

Full Product Details

Author:   Greta Pifat-Mrzljak
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2004 ed.
Dimensions:   Width: 17.80cm , Height: 1.90cm , Length: 25.40cm
Weight:   1.770kg
ISBN:  

9780306486616

ISBN 10:   030648661
Pages:   294
Publication Date:   10 August 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Structural Basis of Protein Synthesis.- The Relationship Between Protein Sequence, Structure and Function.- Differences in Binding of Stereoisomers to Protein Active Sites.- Analytical Centrifugation: Looking at Aggregation in Free Solution.- Time Resolved Protein Fluorescence. Application to Multi-Tryptophan Proteins.- Novel (Bio)chemical and (Photo)physical Probes for Imaging Living Cells.- Observing Structure and Dynamics of Membrane Proteins by High-Resolution Microscopy.- A 2D-Infrared Study of Human Lipoproteins.- An Introduction to Biological Solid State NMR.- Multi-Frequency EPR Spectroscopy Studies of the Structure and Conformational Changes of Site-Directed Spin Labelled Membrane Proteins.- Identification of Protein Structure and its Modifications by Electrospray Mass Spectrometry in Proteomics.- A Microscopic Study of Disorder-Order Transitions in Molecular Recognition of Unstructured Proteins: Hierarchy of Structural Loss and the Transition State Determination from Monte Carlo Simulations of P27KIP1 Protein Coupled Unfolding and Unbinding.- Computational Detection of the Binding Site Hot Spot and Predicting Energetics of Ligand Binding at the Remodeled Human Growth Hormone-Receptor Interface Using a Hierarchy of Molecular Docking and Binding Free Energy Approaches.- Molecular and Cellular Levels of Biological Evolution.

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