Overview

This book delves into the methods of synthesis and functionalization of superparamagnetic materials, offering a deep understanding of their properties and applications. It explores the behavioral study of these materials and provides valuable insights into their diverse applications across various fields. A dedicated section focuses on in vitro and in vivo assessment, toxicology considerations, and post-application aspects. Furthermore, the book summarizes the current development of superparamagnetic materials, including an overview of ongoing clinical trials.

Full Product Details

Author:   Nanasaheb Thorat ,  Niroj Kumar Sahu
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2023
Weight:   0.645kg
ISBN:  

9783031372865

ISBN 10:   3031372867
Pages:   268
Publication Date:   01 September 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Section A. Synthesis and functionalization of superparamagnetic materials 1. Introduction. Ø  Physics and chemistry of Superparamagnetism and superparamagnetic materials Ø  Physical aspect of ferromagnetic materials, difference between ferromagnetic and superparamagnetic materials 2. Synthesis strategies for superparamagnetic materials Ø  Various methods to synthesize superparamagnetic materials such as solvothermal, hydrothermal, co-precipitation etc. Ø  Characterization techniques of the synthesized materials such as X-ray diffraction, Fourier transform infra-red spectroscopy, Thermal studies, surface area analysis, magnetization studies etc.   3. Functionalization strategies of superparamagnetic materials for biocompatibility and targeted drug delivery Ø  Functionalization strategy with some biocompatible polymers, as well as information regarding ligand functionalization for specific drug delivery  Section B. Behavioural study and applications of superparamagnetic materials   4. Mechanistic study of superparamagnetic materials in the body Ø  Rheological parameters/behaviour of nanoparticles in the body, phagocytosis, opsonization mechanism to be explained in detail along with the examples of some biodegradable nanoparticles. Ø  Interaction with body fluids, cells and organs. Surface remodelling of nanoparticles after interaction with bodily fluids. Aggregation and enzymatic attack and their persistence in the organs leading to inflammation should be given in detail 5. Applications of superparamagnetic materials in drug delivery towards cancer therapy Ø  Superparamagnetic nanoparticles and nanoclusters for drug delivery. Ø  Drug delivery mechanism, basics of drug delivery as well significance of shape, size, surface area and porosity of the nanoparticles and clusters in drug delivery to be explained. 6. Applications of superparamagnetic materials in Hyperthermia towards cancer therapy Ø  Computational study, simulation of superparamagnetic materials for magnetic hyperthermia-based cancer therapy. Ø  Significance of anisotropy in shape of the magnetic nanoparticles and clusters in hyperthermia to be explained 7. Superparamagnetic materials in cancer diagnostics Ø  Detailed explanation on MRI and biosensors Ø  Superparamagnetic materials and their composites with Gd(III)/Gd2O3 or Mn(II)/MnO/Mn3O4 for dual mode T1/T2 MR imaging to be explained. Ø  Applications of superparamagnetic materials for theranostics purpose will be illustrated. Ø  Recent findings with last 20-year literature survey         Section C In vitro, In vivo assessment, toxicology and aftermath   8. In vitro and in vivo assessment of superparamagnetic materials Ø Literature survey regarding biocompatibility of superparamagnetic materials on various cell lines Ø Literature survey on testing of drug loaded materials on various cancer cell lines through MTT, SRB assay Ø In vivo assessment of superparamagnetic materials, in vivo antitumor efficiency, biodistribution as well as biocompatibility 9. Pharmacokinetic study of superparamagnetic materials   10. Toxicology of superparamagnetic materials Ø Toxic effects of superparamagnetic materials on various body organs. Ø Some information regarding how to quantify the accumulated nanoparticles must be explained. Clearance mechanism of superparamagnetic materials from the body   Section D. Clinical trials and current development   11. Recent status of the current clinical trials going on for superparamagnetic materials. Ø  Pre-clinical and clinical studies going on for magnetic nanoparticles for ex. magnetic fluid MFL AS developed by MagForce technologies, Germany having superparamagnetic iron oxide nanoparticles for fluid hyperthermia is under clinical trial. Ø  Past studies and future aspects to be explained. 12. Future viewpoint and summary  

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Author Information

Dr. Nanasaheb Thorat, M.Sc., Ph.D., (Gold Medal) MRSC is a Principal Investigator of Cancer Nanomedicine at University of Limerick and awardee of the  Marie-Curie Fellowship in the University of Oxford, Oxford, UK (2020-2022). Dr. Thorat is as fellow of the Royal Society of Medicine London and Recipient of various other prestigious fellowships including Marie Skłodowska-Curie Fellowship (IF) in Poland/Switzerland 2018, Japanese Society for the Promotion of Science (JSPS) Fellowship in Japan 2017, and Government of Ireland IRC fellowship Ireland 2015. Dr. Thorat is Management Committee Member of 3 European Cooperation in Science and Technology (COST) actions such as COST Action CA17140, Cancer Nanomedicine-From The Bench To The Bedside (NANO2CLINIC), CA17104, New Diagnostic And Therapeutic Tools Against Multidrug Resistant Tumors and CA17115, European Network for advancing Electromagnetic Hyperthermic Medical Technologies. Dr. Niroj Kumar Sahu, M.Tech., Ph.D., is Associate Professor working in Centre for Nanotechnology (CNR), Vellore Institute of technology, Vellore. His major research interests include magnetism and magnetic nanomaterials, thermo-chemotherapy, hyperthermia, magnetic resonance imaging, and drug delivery system. He is Lifetime Member of Society for Materials Chemistry (SMC), Magnetic Society of India (MSI), and Materials Research Society of India (MRSI).  

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