Overview

Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in vitro. These observations raise many fascinating questions about the nature of T-cell activation and microbial pathogenesis. This volume is an up-to-date, wide-ranging examination of the function and significance of superantigens in virology, biochemistry, and cell and stuctural biology as well as immunology. The book will interest graduate students and postdoctoral fellows in a wide range of biomedical sciences.

Full Product Details

Author:   Brigitte T. Huber ,  Ed Palmer
Publisher:   Cold Spring Harbor Laboratory Press,U.S.
Imprint:   Cold Spring Harbor Laboratory Press,U.S.
Volume:   v. 7
Dimensions:   Width: 15.40cm , Height: 1.20cm , Length: 22.60cm
Weight:   0.329kg
ISBN:  

9780879693985

ISBN 10:   0879693983
Pages:   182
Publication Date:   01 January 1993
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction (B. Huber, E. Palmer); Structural Model of Staphylococcal Enterotoxin A Interaction with MHC Class II Antigens (J.D. Fraser et al.); Superantigens Expresssed by Mouse Mammary Tumor Virus (H. Acha-Orbea); Superantigen Function in Mouse Mammary Tumor Virus-induced Tumorigenesis (S.R. Ross et al.); Polymorphism of TCR VB Regions and Clonal Deletions in Wild Mouse Populations (P.N. Marche et al.); T-Cell Recognition of Superantigens: Role of Non-VB TCR Elements and MHC Molecules (M.A. Blackman et al.); MTV-encoded Superantigen Expression in B Lymphoma Cells on SJL Mice as a Stimulus for Reversed Immun-ological Surveillance (V.K. Tsiagbe et al.); Superantigenicity of Rabies Virus Nucleocapsid in Humans and Mice (M. Lafon et al.); Superantigens and the Patho-genesis of Viral Diseases (H. Soudeyns et al.); HIV-1 Replication in T Cells Dependent on TCR VB Expression (D.N. Posnett et al.)

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