Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation
Author:   Xiucong Bao
Publisher:   Springer Verlag, Singapore
Edition:   1st ed. 2020
ISBN:  

9789811525087


Pages:   163
Publication Date:   21 March 2020
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation


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Overview

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.

Full Product Details

Author:   Xiucong Bao
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2020
Weight:   0.454kg
ISBN:  

9789811525087


ISBN 10:   9811525080
Pages:   163
Publication Date:   21 March 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction to Protein Posttranslational Modifications (PTMs).- Chemical reporter for Lysine Malonylation.- Identification of Histone Lysine Glutarylation.- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly.- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach.

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