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OverviewThis book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases. Full Product DetailsAuthor: Xiucong BaoPublisher: Springer Verlag, Singapore Imprint: Springer Verlag, Singapore Edition: 1st ed. 2020 Weight: 0.454kg ISBN: 9789811525087ISBN 10: 9811525080 Pages: 163 Publication Date: 21 March 2020 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsIntroduction to Protein Posttranslational Modifications (PTMs).- Chemical reporter for Lysine Malonylation.- Identification of Histone Lysine Glutarylation.- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly.- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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