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Author:   Wayne F. Anderson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2014 ed.
Volume:   1140
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.40cm
Weight:   9.006kg
ISBN:  

9781493903535

ISBN 10:   1493903535
Pages:   344
Publication Date:   04 March 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Data Management in the Modern Structural Biology and Biomedical Research Environment.- Structural Genomics of Human Proteins.- Target Selection for Structural Genomics of Infectious Diseases.- Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery.- High Throughput Cloning for Biophysical Applications.- Expression and Solubility Testing in a High Throughput Environment.- Protein Production for Structural Genomics Using E. coli Expression.- Eukaryotic Expression Systems for Structural Studies.- Automated Cell-free Protein Production Methods for Structural Studies.- Parallel Protein Purification.- Oxidative Refolding from Inclusion Bodies.- High throughput Crystallization Screening.- Screening Proteins for NMR Suitability.- Salvage or Recovery of Failed Targets by in situ Proteolysis.- Salvage of Failed Protein Targets by Reductive Alkylation.- Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy.- Data Collection for Crystallographic Structure Determination.- Structure, Determination, Refinement, and Validation.- Virtual High-Throughput Ligand Screening.- Ligand Screening using Fluorescence Thermal Shift Analysis (FTS).- Ligand Screening using Enzymatic Assays.- Ligand Screening using NMR.- Screening Ligands by X-ray Crystallography.- Case Study – Structural Genomics and Human Protein Kinases.

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