Overview

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists.

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9780128181249

Table of Contents

Reviews

"""The planning of this book and the Sections are laid out in a systematic, convenient way and can be followed very easily by the reader. Each Section meticulously covers the chemistry, synthesis, regulation of their biosynthesis, measurement in blood and tissues, their physiological properties, their metabolism and clearance, their quantitative analysis and clinical usefulness in the various disease states. This has been accomplished with extraordinary insight as to what needs to be known by modern investigators, whether investigational or related to clinical disease outcomes. This book is illuminated by many Tables and Figures, again extremely well thought out and highly useful, taking into account the needs of the reader. What is truly remarkable is the timing of such a well written book. As an example, the coverage of the conjugation and de-conjugation, of steroids and steroid hormone metaboites, including DHEA-S and DHEA, has been carefully considered and is so relevant; as are so many of the sections on mechanisms of steroid hormone action. This book, Steroids in the Laboratory and Clinical Practice, is not only timely but absolutely needed as a new era of interest in the function of steroids is unveiled. This seminal textbook will be used as a guide for the emerging field of steroids, steroid hormones and their metabolites, once considered inert, but now all playing important pivotal functional roles."" --David J Morris D.Phil., Emeritus Professor of Pathology and Laboratory Medicine ""…a comprehensive reference book that addresses the specificity of steroid determinations that can clarify confusion clinicians face with abnormal laboratory results….includes all the information needed to understand key concepts of steroid synthesis, action, and biological effects.…covers both basic and analytical applications of steroids to medicine in one source…..this book should be the “go-to” book for clinicians, researchers, pathologists, laboratorians, analytical biochemists, and students…” --Derek Bagley, Endocrine News"

"""The planning of this book and the Sections are laid out in a systematic, convenient way and can be followed very easily by the reader. Each Section meticulously covers the chemistry, synthesis, regulation of their biosynthesis, measurement in blood and tissues, their physiological properties, their metabolism and clearance, their quantitative analysis and clinical usefulness in the various disease states. This has been accomplished with extraordinary insight as to what needs to be known by modern investigators, whether investigational or related to clinical disease outcomes. This book is illuminated by many Tables and Figures, again extremely well thought out and highly useful, taking into account the needs of the reader. What is truly remarkable is the timing of such a well written book. As an example, the coverage of the conjugation and de-conjugation, of steroids and steroid hormone metaboites, including DHEA-S and DHEA, has been carefully considered and is so relevant; as are so many of the sections on mechanisms of steroid hormone action. This book,Steroids in the Laboratory and Clinical Practice, is not only timely but absolutely needed as a new era of interest in the function of steroids is unveiled. This seminal textbook will be used as a guide for the emerging field of steroids, steroid hormones and their metabolites, once considered inert, but now all playing important pivotal functional roles."" --David J Morris D.Phil., Emeritus Professor of Pathology and Laboratory Medicine"

Author Information

Dr. Honour has 45 years of experience in analyzing steroids mainly by gas chromatography and mass spectrometry and applying these results to the investigation of patients with endocrine disorders. His work has included the diagnosis of inherited disorders of blood pressure, sex determination, infertility, osteoporosis, and salt balance in the body. He has long had an interest in the ability of bacteria to change steroids in the body and has used bacteria in test-tubes to achieve some changes in steroid structure which could not be easily achieved with chemicals. Several research projects have examined the safety of inhaled steroids with respect to effects on the hypothalamic-pituitary-adrenal axis. Dr. Honour is an Honorary Senior Research Associate at the Institute for Women's Health at University College London and formerly a Consultant Clinical Scientist in Clinical Biochemistry at UCLH and Head of the specialist service for Steroid Endocrinology. The steroid laboratory maintains strong links with the clinical endocrinologists at UCL and the Hospital for Children at Great Ormond Street. Research in the unit covered the validation and use of mass spectrometry in steroid analysis for disorders of sex determination, adrenal diseases, polycystic ovary syndrome, safety of corticosteroids in treatment of asthma, links between birthweight and cardiovascular risk, and the enterohepatic circulation of steroids. Dr. Honour has more than 170 refereed publications and 19 book chapters covering a range of analytical, genetic and clinical aspects of steroids. He presented 175 papers at scientific conferences. He was scientific adviser to UKNEQAS for immunoassays, steroid accuracy and pediatric investigations. He served on two working parties for the European Society for Pediatric Endocrinology with the Lawson Wilkins Pediatric Society that produced guidelines on congenital adrenal hyperplasia and newborn screening. An EQA scheme for urinary steroids was operated from UCL globally with the collaboration of the Dutch Foundation for Quality in Clinical Chemistry (SKML). Dr Honour has maintained an interest in the detection of abuse of anabolic steroids in sport and has acted as an expert witness in cases of drug abuse in sport. He is an Associate Editor of the Annals of Clinical Biochemistry.

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